Williams D L, Climie A, Muller H K, Lugg D J
J Clin Lab Immunol. 1986 May;20(1):43-9.
Cell-mediated immune responses were studied in 2 Antarctic and sub-Antarctic groups at quarterly intervals over a wintering year, using the cutaneous CMI Multitest. The sub-Antarctic population at Macquarie Island (M.I.) had levels of responsiveness and hypoergy comparable to other healthy populations in temperate regions. The Antarctic group at Mawson showed decreased scores and total number of positive responses to antigens, and a significantly elevated incidence of anergy and hypoergy. Quarterly skin testing showed considerable variability in subject responsiveness to specific antigens at different times over the year. However, only 2 antigens at M.I., trichophyton and proteus, showed a significant seasonal variation in score. There was no statistically significant seasonal variation in antigen scores at Mawson. It is concluded that environment and stress factors in Antarctic expeditions are responsible for the decreased immunological responsiveness.
在一个越冬年期间，每隔三个月对两个南极和亚南极群体进行细胞介导免疫反应研究，采用皮肤CMI多项测试。麦夸里岛（M.I.）的亚南极群体的反应性和低反应性水平与温带地区的其他健康群体相当。莫森的南极群体对抗原的反应得分和阳性反应总数降低，无反应性和低反应性的发生率显著升高。季度皮肤测试显示，一年中不同时间受试者对特定抗原的反应性存在相当大的差异。然而，在M.I.，只有两种抗原，即毛癣菌和变形杆菌，得分有显著的季节性变化。在莫森，抗原得分没有统计学上显著的季节性变化。得出的结论是，南极探险中的环境和压力因素导致免疫反应性降低。
