Muller H K, Lugg D J, Quinn D
Department of Pathology, University of Tasmania, Hobart, Australia.
Immunol Cell Biol. 1995 Aug;73(4):316-20. doi: 10.1038/icb.1995.48.
Cell-mediated immune responses were studied in 12 Antarctic and sub-Antarctic wintering groups at quarterly intervals over the period 1984-1992, using the cutaneous CMI Multitest. These populations are among the most isolated on earth. While the sub-Antarctic population at Macquarie Island had levels of responsiveness and hypoergy (9%) comparable to healthy populations in temperate zones, the Antarctic Continental group showed a level of hypoergy of 36%. There was no seasonal variation in the pattern of responses. It is concluded that the extreme and isolated environment and stress factors are responsible for the decreased immunological responsiveness but the mechanisms are presently unclear. On review, one factor appears to be perceived anxiety. The high rate of hypoergy in Antarctica, where medical care is limited, may have health implications. These groups provide an excellent analogue for immunological investigations in longer term space flight.
1984年至1992年期间，每隔一个季度，使用皮肤细胞介导免疫多项检测法对12个南极和亚南极越冬群体的细胞介导免疫反应进行了研究。这些群体是地球上最与世隔绝的群体之一。虽然麦夸里岛的亚南极群体的反应性和低反应性水平（9%）与温带地区的健康群体相当，但南极大陆群体的低反应性水平为36%。反应模式没有季节性变化。得出的结论是，极端和孤立的环境以及压力因素导致免疫反应性降低，但目前机制尚不清楚。经审查，一个因素似乎是感知到的焦虑。在医疗条件有限的南极洲，高比例的低反应性可能对健康有影响。这些群体为长期太空飞行中的免疫学研究提供了一个很好的类似物。
