Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Department of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Ann Clin Transl Neurol. 2023 Sep;10(9):1502-1512. doi: 10.1002/acn3.51839. Epub 2023 Jun 24.
To determine whether white matter hyperintensity (WMH) volumes in specific regions are associated with Parkinson's disease (PD) compared to non-PD controls, and to assess their impact on motor signs through cross-sectional and longitudinal analyses.
A total of 50 PD participants and 47 age- and gender-matched controls were enrolled. All PD participants were followed up for at least 2 years. To detect regions of greater WMH in the PD, the WMH volume of each region was compared with the corresponding region in the control group. Linear regression and linear mixed effects models were respectively used for cross-sectional and longitudinal analyses of the impact of increases in WMH volume on motor signs.
The PD group had greater WMH volume in the occipital region compared with the control group. Cross-sectional analyses only detected a significant correlation between occipital WMH volume and motor function in PD. Occipital WMH volume positively correlated with the severity of tremor, and gait and posture impairments, in the PD group. During the follow-up period, the participants' motor signs progressed and the WMH volumes remained stable, no longitudinal association was detected between them. The baseline occipital WMH volume cannot predict the progression of signs after adjustment for baseline disease duration and the presence of vascular risk factors.
PD participants in this study were characterized by greater WMH at the occipital region, and greater occipital WMH volume had cross-sectional associations with worse motor signs, while its longitudinal impact on motor signs progression was limited.
确定与非帕金森病（PD）对照组相比，特定区域的脑白质高信号（WMH）体积是否与 PD 相关，并通过横断面和纵向分析评估其对运动体征的影响。
共纳入 50 名 PD 参与者和 47 名年龄和性别匹配的对照组。所有 PD 参与者均至少随访 2 年。为了检测 PD 患者中更大的 WMH 区域，将每个区域的 WMH 体积与对照组的相应区域进行比较。线性回归和线性混合效应模型分别用于横断面和纵向分析 WMH 体积增加对运动体征的影响。
PD 组的枕叶区域的 WMH 体积大于对照组。横断面分析仅在 PD 中检测到枕叶 WMH 体积与运动功能之间存在显著相关性。枕叶 WMH 体积与 PD 组震颤、步态和姿势障碍的严重程度呈正相关。在随访期间，参与者的运动体征进展，WMH 体积保持稳定，未检测到它们之间的纵向关联。在调整基线疾病持续时间和血管危险因素存在后，基线枕叶 WMH 体积不能预测体征的进展。
本研究中的 PD 参与者的特征是枕叶区域有更大的 WMH，更大的枕叶 WMH 体积与更差的运动体征有横断面相关性，而其对运动体征进展的纵向影响有限。
