海洋来源真菌 Y20-2 的次生代谢产物及其促血管生成活性。
Secondary metabolites from the marine-derived fungus Y20-2, and their pro-angiogenic activity.
机构信息
Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Shandong Provincial Engineering Laboratory for Biological Testing Technology, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Yucheng People's Hospital, Dezhou 253000, China.
出版信息
Z Naturforsch C J Biosci. 2023 Jun 26;78(9-10):345-352. doi: 10.1515/znc-2022-0198. Print 2023 Sep 26.
A systematic chemical study of the secondary metabolites of the marine fungus, (No. Y20-2), led to the isolation of 21 compounds, one of which is new (compound ). The structures of the 21 compounds were determined by conducting extensive analysis of the spectroscopic data. The pro-angiogenic activity of each compound was evaluated using a zebrafish model. The results showed that compounds , , , and had strong and dose-dependent pro-angiogenic effects, with compound demonstrating the strongest pro-angiogenic activity, compounds , , , and showing moderate activity, and compounds , , and exhibiting relatively weak activity.
对海洋真菌（No. Y20-2）的次生代谢产物进行系统的化学研究，分离得到 21 种化合物，其中一种为新化合物（化合物 ）。通过对光谱数据的广泛分析，确定了 21 种化合物的结构。采用斑马鱼模型评价了每种化合物的促血管生成活性。结果表明，化合物 、 、 、 具有较强的、剂量依赖性的促血管生成作用，其中化合物 促血管生成活性最强，化合物 、 、 具有中等活性，化合物 、 、 活性较弱。
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