Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan, China.
Nat Prod Res. 2023 May;37(10):1702-1708. doi: 10.1080/14786419.2022.2103813. Epub 2022 Jul 25.
A total of 14 compounds including a novel tetrasubstituted benzene derivative peniprenylphenol A were isolated from a scaled-up culture of the Indonesian mangrove sediment-derived fungus ZZ1151 in rice medium. Structures of the isolated compounds were determined based on their NMR spectroscopic analyses, HRESIMS data, optical rotation calculations and comparison with the reported data. New peniprenylphenol A () was found to have antimicrobial activities against human pathogenic methicillin-resistant (MRSA), and with MIC values of 6, 13, and 13 µg/mL, respectively. The known compounds of penicimumide (), preparaherquamide (), uridine (), thymine (), 1,2-seco-trypacidin () communol G (), clavatol (), 4-hydroxybenzeneacetic acid methyl ester (), 2,5-dihydroxyphenylacetic acid methyl ester (), 2-hydroxyphenylacetic acid methyl ester () and 4-hydroxyphenylethanone () showed antimicrobial activity against at least one of the three tested pathogens with MIC values of 3-25 µg/mL.
从印度尼西亚红树林沉积物来源的真菌 ZZ1151 在大米培养基中的规模化培养物中分离得到了 14 种化合物，包括一种新型的四取代苯衍生物 peniprenylphenol A。根据其 NMR 光谱分析、HRESIMS 数据、旋光计算以及与报道数据的比较，确定了分离化合物的结构。新的 peniprenylphenol A () 对人类致病菌耐甲氧西林金黄色葡萄球菌 (MRSA) 和 具有抗菌活性，MIC 值分别为 6、13 和 13μg/mL。penicimumide ()、preparaherquamide ()、尿嘧啶 (), thymine (), 1,2-seco-trypacidin () communol G (), clavatol (), 4-hydroxybenzeneacetic acid methyl ester (), 2,5-dihydroxyphenylacetic acid methyl ester (), 2-hydroxyphenylacetic acid methyl ester () 和 4-hydroxyphenylethanone () 等已知化合物对至少一种三种测试病原体均具有抗菌活性，MIC 值为 3-25μg/mL。
