斑马鱼模型在海洋生物活性分子发现中的最新进展

Recent Advances of the Zebrafish Model in the Discovery of Marine Bioactive Molecules.

作者信息

Liu Changyu, Li Jiaxun, Wang Dexu, Liu Jibin, Liu Kechun, Li Peihai, Zhang Yun

机构信息

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.

Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Key Laboratory for Biosensor of Shandong Province, Jinan 250103, China.

出版信息

Mar Drugs. 2024 Nov 30;22(12):540. doi: 10.3390/md22120540.

DOI:10.3390/md22120540

PMID:39728115

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11678508/

Abstract

Marine natural products are increasingly utilized in nutrition, cosmetics, and medicine, garnering significant attention from researchers globally. With the expansion of marine resource exploration in recent years, the demand for marine natural products has risen, necessitating rapid and cost-effective activity evaluations using model organisms. Zebrafish, a valuable vertebrate model, has become an efficient tool for screening and identifying safe, active molecules from marine natural products. This review, based on nearly 10 years of literature, summarizes the current status and progress of zebrafish models in evaluating marine natural product bioactivity. It also highlights their potential in exploring marine resources with health benefits, offering a reference for the future development and utilization of marine biological resources.

摘要

海洋天然产物在营养、化妆品和医学领域的应用日益广泛，受到全球研究人员的高度关注。近年来，随着海洋资源勘探的不断扩展，对海洋天然产物的需求日益增加，因此需要使用模式生物进行快速且经济高效的活性评估。斑马鱼作为一种有价值的脊椎动物模型，已成为从海洋天然产物中筛选和鉴定安全、活性分子的有效工具。本综述基于近十年的文献，总结了斑马鱼模型在评估海洋天然产物生物活性方面的现状和进展。它还强调了斑马鱼模型在探索具有健康益处的海洋资源方面的潜力，为海洋生物资源的未来开发和利用提供参考。