冷泉沉积物来源的橄榄霉素新种。
New Olimycins from a Cold-Seep-Derived Streptomyces olivaceus.
机构信息
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237, China.
出版信息
Chem Biodivers. 2023 Aug;20(8):e202300689. doi: 10.1002/cbdv.202300689. Epub 2023 Jul 11.
Cold-seeps are areas of the ocean floor in which hydrogen sulfide and methane are released into the open water. The cold-seep microbes are an emerging source of novel bioactive natural products. Four new ansa-ring opened linear ansamycin analogues, named olimycins E-H (1-4) were isolated from the cold-seep-derived Streptomyces olivaceus OUCLQ19-3. The planar and stereochemical structures of the isolated compounds were elucidated based on extensive MS and NMR spectroscopic analyses together with ECD calculations.
冷泉是海底的一些区域，其中硫化氢和甲烷被释放到开阔的水域中。冷泉微生物是新型生物活性天然产物的新兴来源。从冷泉衍生的橄榄色链霉菌 OUCLQ19-3 中分离到四个新的ansa-环开链 ansamycin 类似物，命名为奥利霉素 E-H（1-4）。基于广泛的 MS 和 NMR 光谱分析以及 ECD 计算，确定了分离化合物的平面和立体化学结构。
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