阻塞性睡眠呼吸暂停、循环 microRNAs 与心血管疾病风险。

Obstructive sleep apnea, circulating microRNAs, and risk of cardiovascular disease.

机构信息

Université Paris Cité, INSERM, UMR-S970, Paris Cardiovascular Research Center, Team "Integrative Epidemiology of Cardiovascular Diseases", Paris, France; Department of Head and Neck Surgery, Foch Hospital, Suresnes, France.

Department of Medicine, Internal Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland.

出版信息

Sleep Med. 2023 Sep;109:1-3. doi: 10.1016/j.sleep.2023.06.006. Epub 2023 Jun 17.

DOI:10.1016/j.sleep.2023.06.006

PMID:37354730

Abstract

OBJECTIVE

while obstructive sleep apnea is strongly associated with incident cardiovascular diseases (CVD), the underlying mechanisms remain to be elucidated. This study aimed to compare the patterns of microRNAs expression between OSA and control patients with and without incident CVD.

METHODS

218 matched adult participants with and without OSA and with and without incident CVD were selected from two independent community-based prospective cohorts in France and Switzerland, and 168 microRNAs on average were detected per sample. OSA was diagnosed using the validated Berlin questionnaire in one study (Paris Prospective Study 3) and during a full-night polysomnography in the second study (HypnoLaus Study).

RESULTS

there were 78 OSA patients (39 with and 39 without CVD) and 140 controls (70 with and 70 without CVD). Participants were male in 54.6% (n = 119) and mean age was 58.7 years (±9.2). Of the 183 miRNAs screened, a mean 168 assays were detected per sample, and 129 in all samples. There was no pattern of blood microRNAs expression that discriminated OSA patients with and without CVD events.

CONCLUSIONS

this binational study failed to find any association between a large panel of microRNAs and OSA patients with and without incident CVD.

摘要

目的

尽管阻塞性睡眠呼吸暂停（OSA）与心血管疾病（CVD）的发生密切相关，但其中的潜在机制仍有待阐明。本研究旨在比较伴有和不伴有 CVD 事件的 OSA 患者与对照组患者之间 microRNAs 表达模式的差异。

方法

从法国和瑞士的两个独立的基于社区的前瞻性队列中选择了 218 对匹配的成年参与者，其中包括伴有和不伴有 OSA 以及伴有和不伴有 CVD 的患者，每个样本平均检测了 168 个 microRNAs。在一项研究（巴黎前瞻性研究 3）中使用经过验证的柏林问卷诊断 OSA，在第二项研究（HypnoLaus 研究）中在整夜多导睡眠图监测期间诊断 OSA。

结果

共有 78 名 OSA 患者（39 名伴有和 39 名不伴有 CVD）和 140 名对照组患者（70 名伴有和 70 名不伴有 CVD）。参与者中男性占 54.6%（n=119），平均年龄为 58.7 岁（±9.2）。在筛选的 183 个 microRNAs 中，每个样本平均检测到 168 个检测，所有样本共检测到 129 个。没有血液 microRNAs 表达模式可以区分伴有和不伴有 CVD 事件的 OSA 患者。