Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
J Nutr. 2023 Aug;153(8):2291-2297. doi: 10.1016/j.tjnut.2023.06.021. Epub 2023 Jun 23.
The cardioprotective diet has been previously reported to be inversely associated with the development of inflammatory bowel disease (IBD), but whether it is beneficial to improve adverse outcomes in IBD remains unknown.
We aimed to investigate whether the cardioprotective diet is associated with enterotomy and all-cause mortality among individuals with IBD.
We conducted a prospective cohort study of 5549 participants with IBD from the UK Biobank. Cardioprotective diet scores (range 0-7) were calculated based on the consumption of 7 common food groups collected by a validated food frequency questionnaire. Outcomes of interest were enterotomy and all-cause mortality, ascertained via inpatient data and death registry, respectively. Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).
During an average follow-up duration of 12.0 y, we documented 506 enterotomy and 566 death events. Compared with participants with the lowest adherence to the cardioprotective diet (score of 0-2), participants with the highest adherence to the cardioprotective diet (score of 5-7) were observed to have a lower risk of enterotomy (HR: 0.60; 95% CI: 0.47, 0.76; P < 0.001; P-trend < 0.001) and all-cause mortality (HR: 0.77; 95% CI: 0.61, 0.98; P = 0.031; P-trend = 0.025).
A greater adherence to the cardioprotective diet is associated with a lower risk of enterotomy and all-cause mortality among individuals with IBD.
先前有报道称，护心饮食与炎症性肠病（IBD）的发展呈负相关，但它是否有益于改善 IBD 的不良结局尚不清楚。
我们旨在研究护心饮食是否与 IBD 患者的肠切开术和全因死亡率相关。
我们对来自英国生物库的 5549 名 IBD 患者进行了一项前瞻性队列研究。根据通过验证的食物频率问卷收集的 7 种常见食物组的摄入情况，计算护心饮食评分（范围 0-7）。感兴趣的结局是通过住院数据和死亡登记分别确定的肠切开术和全因死亡率。使用 Cox 比例风险模型估计风险比（HR）和 95％置信区间（CI）。
在平均 12.0 年的随访期间，我们记录了 506 例肠切开术和 566 例死亡事件。与护心饮食最低依从性（评分 0-2）的参与者相比，护心饮食最高依从性（评分 5-7）的参与者发生肠切开术的风险较低（HR：0.60；95％CI：0.47，0.76；P<0.001；P-趋势<0.001）和全因死亡率（HR：0.77；95％CI：0.61，0.98；P=0.031；P-趋势=0.025）。
护心饮食的依从性越高，IBD 患者发生肠切开术和全因死亡率的风险越低。
