Kuehl Rea, Koeppel Maximilian, Goldschmidt Hartmut, Maatouk Imad, Rosenberger Friederike, Wiskemann Joachim
Working Group Exercise Oncology, Division of Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany.
Department of Internal Medicine V, University Hospital Heidelberg and National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
Ann Hematol. 2023 Nov;102(11):3091-3102. doi: 10.1007/s00277-023-05326-y. Epub 2023 Jun 24.
The purpose of this study is to ensure best possible supply of exercise therapy to patients with multiple myeloma (MM); it is helpful to identify patient groups with similar symptom burden and physical activity-related health competences (PAHCO). Latent profile analyses (LPA) of MM patients were used to identify profiles of patients with similar PAHCO and symptom burden. Analysis of variance was applied to investigate group differences in important covariates. N = 98 MM patients (57% male, age 64 ± 9 years) could be assigned to three distinct PAHCO profiles: 46% were patients with high PAHCO, 48% patients with moderate, and 5% were patients with low PAHCO. The mean probability to be assigned to a certain profile was over 99%. The first group showed significant higher physical activity (PA) and lower comorbidities. Regarding symptom burden, three different profiles exist, including group one (32% of patients) with very low symptom burden, profile two (40%) with medium symptom burden, and group three (15%) with very high symptom burden (mean probability ≥ 98%). Patients in profile one had a lower number of treatment lines compared to the other profiles. Patients who were assigned to the high PAHCO profile were more likely to display a milder symptoms profile. In this exploratory analysis, we identified different patient profiles for PAHCO and symptom burden that may be used to individualize exercise recommendations and supervision modalities in MM patients. PAHCO and symptom burden level may be used to stratify MM patients in order to provide more personalized and effective exercise counseling. The profiles require individualized exercise recommendations and different supervision modalities, including educational instructions tailored particularly to every patient's needs, according to their PAHCO and symptom profile. TRIAL REGISTRATION NUMBER: NCT04328038.
本研究的目的是确保为多发性骨髓瘤（MM）患者提供尽可能最佳的运动疗法；识别具有相似症状负担和与身体活动相关的健康能力（PAHCO）的患者群体很有帮助。对MM患者进行潜在类别分析（LPA），以识别具有相似PAHCO和症状负担的患者类别。应用方差分析来研究重要协变量的组间差异。N = 98例MM患者（57%为男性，年龄64±9岁）可分为三种不同的PAHCO类别：46%为PAHCO高的患者，48%为中等的患者，5%为低的患者。被分配到某一特定类别的平均概率超过99%。第一组显示出显著更高的身体活动（PA）和更低的合并症。关于症状负担，存在三种不同的类别，包括症状负担极低的第一组（32%的患者）、中等症状负担的第二组（40%）和症状负担极高的第三组（15%）（平均概率≥98%）。与其他类别相比，第一类别的患者治疗线数更少。被分配到高PAHCO类别的患者更有可能表现出较轻的症状类别。在这项探索性分析中，我们识别出了PAHCO和症状负担的不同患者类别，这些类别可用于个性化MM患者的运动建议和监督方式。PAHCO和症状负担水平可用于对MM患者进行分层，以便提供更个性化和有效的运动咨询。这些类别需要个性化的运动建议和不同的监督方式，包括根据每个患者的PAHCO和症状类别特别为其需求量身定制的教育指导。试验注册号：NCT04328038。
