酒精使用障碍作为认知障碍的风险因素。
Alcohol Use Disorder as a Risk Factor for Cognitive Impairment.
机构信息
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The College, University of California at Los Angeles, Los Angeles, CA, USA.
出版信息
J Alzheimers Dis. 2023;94(3):899-907. doi: 10.3233/JAD-230181.
BACKGROUND
Alcohol use disorder (AUD) is a worldwide problem. The AUD can take the form of hazardous drinking, binge drinking, or alcohol dependence. The effects of alcohol on cognition can be diverse and complex.
OBJECTIVE
Our study aimed to assess AUD as a risk factor for cognitive impairment.
METHODS
A literature search was conducted using major electronic databases of PubMed, EMBASE, and Web of Science. Abstracts were screened independently to include data from original research reports. The following keywords were used: alcohol abuse, cognitive impairment, Alzheimer's disease, and dementia. In total, 767 abstracts were retrieved. After removing the duplicates, 76 articles met the criteria for full-text review, of which 41 were included in this report.
RESULTS
People with AUD are seen from different geographical areas and cultures. AUD is associated with an increased risk of cognitive impairments, Alzheimer's disease, and dementia, especially vascular dementia. In addition, AUD interacts with comorbidities increasing the risk of cognitive impairment.
CONCLUSION
AUD is associated with an increased risk of cognitive impairments, which may have more than one underlying mechanism.
背景
酒精使用障碍（AUD）是一个全球性问题。AUD 可以表现为危险饮酒、狂饮或酒精依赖。酒精对认知的影响可能是多种多样且复杂的。
目的
我们的研究旨在评估 AUD 作为认知障碍的一个风险因素。
方法
使用 PubMed、EMBASE 和 Web of Science 等主要电子数据库进行文献检索。独立筛选摘要以纳入来自原始研究报告的数据。使用的关键词有：酒精滥用、认知障碍、阿尔茨海默病和痴呆。共检索到 767 篇摘要。去除重复项后，有 76 篇文章符合全文审查标准，其中 41 篇被纳入本报告。
结果
来自不同地理区域和文化的人群都存在 AUD。AUD 与认知障碍、阿尔茨海默病和痴呆的风险增加有关，尤其是血管性痴呆。此外，AUD 与合并症相互作用会增加认知障碍的风险。
结论
AUD 与认知障碍的风险增加有关，其潜在机制可能不止一种。
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