夜间户外光照（光污染）与阿尔茨海默病有关。
Outdoor nighttime light exposure (light pollution) is associated with Alzheimer's disease.
作者信息
Voigt Robin M, Ouyang Bichun, Keshavarzian Ali
机构信息
Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, United States.
Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.
出版信息
Front Neurosci. 2024 Sep 6;18:1378498. doi: 10.3389/fnins.2024.1378498. eCollection 2024.
INTRODUCTION
Alzheimer's disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. Exposure to artificial light at night is one environmental factor that may influence AD.
METHODS
This study evaluated the relationship between outdoor nighttime light exposure and AD prevalence in the United States using satellite acquired outdoor nighttime light intensity and Medicare data.
RESULTS
Higher outdoor nighttime light was associated with higher prevalence of AD. While atrial fibrillation, diabetes, hyperlipidemia, hypertension, and stroke were associated more strongly with AD prevalence than nighttime light intensity, nighttime light was more strongly associated with AD prevalence than alcohol abuse, chronic kidney disease, depression, heart failure, and obesity. Startlingly, nighttime light exposure more strongly associated with AD prevalence in those under the age of 65 than any other disease factor examined.
DISCUSSION
These data suggest light exposure at night may influence AD, but additional studies are needed.
引言
在上个世纪，阿尔茨海默病（AD）的患病率有所上升，这可能归因于寿命延长，但环境因素也很重要。夜间暴露于人造光下是一个可能影响AD的环境因素。
方法
本研究利用卫星获取的室外夜间光强度和医疗保险数据，评估了美国室外夜间光照暴露与AD患病率之间的关系。
结果
较高的室外夜间光照与较高的AD患病率相关。虽然心房颤动、糖尿病、高脂血症、高血压和中风与AD患病率的关联比夜间光强度更强，但夜间光照与AD患病率的关联比酗酒、慢性肾病、抑郁症、心力衰竭和肥胖更强。令人惊讶的是，在65岁以下人群中，夜间光照暴露与AD患病率的关联比任何其他检查的疾病因素都更强。
讨论
这些数据表明夜间光照暴露可能影响AD，但还需要更多的研究。
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