School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China.
Colloids Surf B Biointerfaces. 2023 Aug;228:113424. doi: 10.1016/j.colsurfb.2023.113424. Epub 2023 Jun 22.
The increasing emergence of drug-resistant bacteria and bacteria-infected wounds highlights the urgent need for new kinds of antibacterial wound dressing. Herein, we reported a novel bio-adhesive and antibacterial hydrogel consisting of hydrophobically modified gelatin, oxidized konjac glucomannan, and dopamine. This kind of functional hydrogel was endowed with developed stability in a liquid environment and strong tissue adhesion, even much higher than the commercial fibrin glue to wounds. The excellent bacteria-killing efficiency of hydrophobically modified hydrogel against S. aureus and E. coli was verified, as well as the low hemolysis ratio against erythrocytes in vitro. The hydrogel also exhibited good cytocompatibility in terms of supporting cell proliferation. Most importantly, these abovementioned properties could be customized by altering the substitution degree of hydrophobic groups during manufacturing, demonstrating its great potential in biomedical fields such as tissue adhesive and wound dressing.
耐药菌和细菌感染伤口的不断出现，凸显了对新型抗菌伤口敷料的迫切需求。在此，我们报道了一种由疏水性改性明胶、氧化魔芋葡甘露聚糖和多巴胺组成的新型生物粘附性和抗菌水凝胶。这种功能性水凝胶在液体环境中具有出色的稳定性和强组织粘附性，甚至比商业纤维蛋白胶对伤口的粘附性还要高。疏水性改性水凝胶对金黄色葡萄球菌和大肠杆菌的杀菌效率得到了验证，体外对红细胞的溶血率也较低。水凝胶在支持细胞增殖方面也表现出良好的细胞相容性。最重要的是，这些性能可以通过在制造过程中改变疏水性基团的取代度来定制，这表明其在组织粘合剂和伤口敷料等生物医学领域具有巨大的潜力。
