Department of Materials Science and Engineering, Faculty of Engineering & Technology, Tarbiat Modares University, P. O. Box: 14115-143, Tehran, Iran.
Department of Materials Science and Engineering, Faculty of Engineering & Technology, Tarbiat Modares University, P. O. Box: 14115-143, Tehran, Iran.
Biomater Adv. 2023 Oct;153:213530. doi: 10.1016/j.bioadv.2023.213530. Epub 2023 Jun 20.
Biocompatible fibrous scaffold containing polyvinyl alcohol (PVA), 70S30C bioactive glass (BG), silver (Ag) nanoparticles and curcumin (Cur) was fabricated through electrospinning method. Scanning electron microscope (SEM) and Field emission scanning electron microscopy (FESEM) were employed to investigate the morphological characteristics of the scaffolds. In addition, biodegradability, hydrophilicity, and contact angle were studied as criteria for evaluating physical properties of the scaffolds. Tensile strength was reported to be 0.971 ± 0.093 MPa. Also, the viability of fibroblasts after 7 days of cell culture was 93.58 ± 1.36 %. The antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria was illustrated using inhibition zones of 13.12 ± 0.69 and 14.21 ± 1.37 mm, respectively. Histological results revealed that tissue regeneration after 14 days of surgery was much higher for the dressing group compared to the blank group. According to the obtained results, the authors introduce the PVA-BG-Ag-Cur scaffold as a promising candidate for skin tissue engineering applications.
通过静电纺丝法制备了含有聚乙烯醇（PVA）、70S30C 生物活性玻璃（BG）、银（Ag）纳米粒子和姜黄素（Cur）的生物相容性纤维状支架。扫描电子显微镜（SEM）和场发射扫描电子显微镜（FESEM）用于研究支架的形态特征。此外，还研究了可生物降解性、亲水性和接触角作为评价支架物理性能的标准。报告的拉伸强度为 0.971 ± 0.093 MPa。此外，在细胞培养 7 天后成纤维细胞的存活率为 93.58 ± 1.36%。通过抑菌圈分别为 13.12 ± 0.69 和 14.21 ± 1.37 mm 来表明对大肠杆菌和金黄色葡萄球菌细菌的抗菌活性。组织学结果表明，与空白组相比，手术后 14 天实验组的组织再生更高。根据获得的结果，作者将 PVA-BG-Ag-Cur 支架介绍为皮肤组织工程应用的有前途的候选物。
