Lim Klay Puay Khim, Lee Aaron Jia Loong, Jiang Xiuting, Teng Thomas Zheng Jie, Shelat Vishal G
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Department of General Surgery, Tan Tock Seng Hospital, Singapore.
Ann Hepatobiliary Pancreat Surg. 2023 Aug 31;27(3):241-250. doi: 10.14701/ahbps.22-056. Epub 2023 Jun 26.
is a gram-negative pathogen commonly associated with peptic ulcer disease and gastric cancer. infection has also been reported in cholelithiasis, cholecystitis, gallbladder polyps, and biliary tract cancers. However, the association between and gallbladder and biliary tract pathologies remains unclear due to the paucity of literature. In response to the current literature gap, we aim to review and provide an updated summary of the association between with gallbladder and biliary tract diseases and its impact on their clinical management. Relevant peer-reviewed studies were retrieved from Medline, PubMed, Embase, and Cochrane databases. We found that infection was associated with cholelithiasis, chronic cholecystitis, biliary tract cancer, primary sclerosing cholangitis, and primary biliary cholangitis but not with gallbladder polyps. While causal links have been reported, prospective longitudinal studies are required to conclude the association between and gallbladder pathologies. Clinicians should be aware of the implications that infection has on the management of these diseases.
是一种革兰氏阴性病原体，通常与消化性溃疡疾病和胃癌相关。也有报道称其感染存在于胆结石、胆囊炎、胆囊息肉和胆管癌中。然而，由于文献匮乏，与胆囊和胆道病理之间的关联仍不清楚。为了回应当前的文献空白，我们旨在回顾并提供关于与胆囊和胆道疾病之间关联及其对临床管理影响的最新总结。从Medline、PubMed、Embase和Cochrane数据库中检索了相关的同行评审研究。我们发现感染与胆结石、慢性胆囊炎、胆管癌、原发性硬化性胆管炎和原发性胆汁性胆管炎相关，但与胆囊息肉无关。虽然已有因果关系的报道，但需要前瞻性纵向研究来确定与胆囊病理之间的关联。临床医生应意识到感染对这些疾病管理的影响。
