蓖麻子诱发瘙痒评分和当前感知阈值评估敏感性皮肤：一项观察性实验室研究。

Cowhage-induced itch scores and the current perception threshold in assessing sensitive skin: An observational laboratory study.

机构信息

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

Department of Radiology of West China Hospital, China Huaxi MR Research Center (HMRRC), Sichuan University, Chengdu, China.

出版信息

Skin Res Technol. 2023 Jun;29(6):e13387. doi: 10.1111/srt.13387.

DOI:10.1111/srt.13387

PMID:37357643

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10242191/

Abstract

BACKGROUND

The diagnosis of sensitive skin remains nonuniform, and the underlying mechanism is unclear. Previous studies were inconsistent in the current perception threshold (CPT) measurement for sensitive skin; thus, the neural sensitivity of sensitive skin needs to be clarified.

OBJECTIVES

This study aimed to compare the CPT measurement and the cowhage test for sensitive skin and to investigate the correlation between CPT values and cowhage-itch scores.

METHODS

Participants with and without sensitive skin (n = 30, 30) were included. The cowhage test and CPT measurement with its related sensations were performed.

RESULTS

No difference was found in CPT between the sensitive and nonsensitive groups at either the site of the face or the forearm (5, 250, or 2000 Hz). Once the CPT was reached, sensations (itch, stinging, and throbbing) were significantly different between the two groups. Cowhage provoked more intense itch with a longer duration in the face (visual analog scale [VAS] score 1.90 ± 1.47 vs. 0.52 ± 0.90, p < 0.001; duration 3.80 ± 3.31 vs. 0.87 ± 1.43 min, p < 0.001) and forearm (VAS 2.53 ± 2.60 vs. 0.72 ± 1.06, p < 0.001; duration 3.37 ± 3.46 vs. 1.33 ± 2.14 min, p < 0.01) of the sensitive group compared with the nonsensitive group. Cowhage-induced itch and CPT-related itch (5 Hz) showed moderate correlations in both the face (r = 0.441, p < 0.001) and forearm (r = 0.491 p < 0.001) and weak correlations in the forearm (r = 0.323 at 250 Hz, p = 0.012; r = 0.376 at 2000 Hz, p = 0.003).

CONCLUSIONS

Cowhage test showed better performance in assessing the neural sensitivity of sensitive skin in comparison with the CPT measurement. Evaluation of CPT-related sensations may add valuable information to sensitive skin assessment.

摘要

背景

敏感皮肤的诊断仍然不一致，其潜在机制尚不清楚。先前的研究在敏感皮肤的当前感知阈值（CPT）测量上存在不一致，因此需要阐明敏感皮肤的神经敏感性。

目的

本研究旨在比较敏感皮肤的 CPT 测量和蕈麻测试，并研究 CPT 值与蕈麻瘙痒评分之间的相关性。

方法

纳入有和无敏感皮肤的参与者（n=30，30 人）。进行蕈麻测试和 CPT 测量及其相关感觉。

结果

面部和前臂的敏感组和非敏感组之间的 CPT 无差异（5、250 或 2000 Hz）。一旦达到 CPT，两组之间的感觉（瘙痒、刺痛和悸动）有显著差异。蕈麻在面部引起更强烈的瘙痒，持续时间更长（视觉模拟评分 [VAS] 1.90±1.47 比 0.52±0.90，p<0.001；持续时间 3.80±3.31 比 0.87±1.43 min，p<0.001）和前臂（VAS 2.53±2.60 比 0.72±1.06，p<0.001；持续时间 3.37±3.46 比 1.33±2.14 min，p<0.01）。与非敏感组相比，敏感组蕈麻引起的瘙痒和 CPT 相关瘙痒（5 Hz）在面部（r=0.441，p<0.001）和前臂（r=0.491，p<0.001）之间呈中度相关，在前臂之间呈弱相关（250 Hz 时 r=0.323，p=0.012；2000 Hz 时 r=0.376，p=0.003）。