Turk Psikiyatri Derg. 2023 Summer;34(2):133-135. doi: 10.5080/u26681.
Aripiprazole, a second-generation antipsychotic (SGA) medication, is an efficacious treatment for schizophrenia and bipolar disorder. However, its effects on pregnancy and lactation are not yet fully documented. Despite aripiprazole being available since 2002, there is only limited information on the risks and benefits of this treatment during pregnancy. Most of the information is limited to populationbased studies examining malformation risk or case studies or small case series. The knowledge in this topic is still insufficient and there is a need to expand the literature. In this report, we present 2 cases exposed to aripiprazole during pregnancy and lactational period. In both our cases of aripiprazole exposure, no teratogenic effects were reported, and it was reassuring that the mothers did not develop gestational diabetes. However, both patients reported lactation failure. Keyword: Mental illness, antipsychotics, aripiprazole, pregnancy.
阿立哌唑，一种第二代抗精神病药物（SGA），是一种有效的精神分裂症和双相情感障碍治疗药物。然而，其对妊娠和哺乳的影响尚未得到充分记录。尽管阿立哌唑自 2002 年以来就已上市，但关于妊娠期间使用这种药物的风险和益处的信息非常有限。大多数信息仅限于基于人群的研究，研究畸形风险或病例研究或小病例系列。在这个主题上，知识仍然不足，需要扩大文献。在本报告中，我们介绍了 2 例在妊娠和哺乳期暴露于阿立哌唑的病例。在我们的阿立哌唑暴露病例中，均未报告致畸作用，令人欣慰的是，母亲未发生妊娠期糖尿病。然而，两名患者均报告出现哺乳失败。关键词：精神疾病、抗精神病药物、阿立哌唑、妊娠。
