Department I of Internal Medicine, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany.
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Antimicrob Agents Chemother. 2023 Jul 18;67(7):e0025123. doi: 10.1128/aac.00251-23. Epub 2023 Jun 26.
Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome inhibitors (MJ-22 and B6) targeting the Mycobacterium tuberculosis respiratory chain with excellent intracellular activities in human macrophages. Both hit compounds revealed very low mutation frequencies and distinct cross-resistance patterns with other advanced cytochrome inhibitors.
耐多药结核病是一种全球卫生保健威胁，需要新型有效的治疗选择。在这里，我们报告了两种新型细胞色素 抑制剂（MJ-22 和 B6），它们针对分枝杆菌呼吸链，在人巨噬细胞中有极好的细胞内活性。这两种命中化合物显示出非常低的突变频率和与其他先进的细胞色素 抑制剂的不同交叉耐药模式。
