Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.
Eye Center, Medical Center-Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Transl Vis Sci Technol. 2023 Jun 1;12(6):20. doi: 10.1167/tvst.12.6.20.
To quantify visual performance of patients with achromatopsia at various contrast and luminance combinations typical for daily living conditions, in comparison to controls, and to measure beneficial effects of short-wavelength cutoff filter glasses used by patients with achromatopsia to reduce glare sensation.
Best-corrected visual acuity (BCVA) was tested with Landolt rings using an automated device (VA-CAL test). The visual acuity space was assessed for each participant with and without filter glasses (transmission >550 nm) at 46 contrast-luminance combinations (18%-95%; 0-10,000 cd/m2). The BCVA differences between both conditions were calculated for each combination as absolute values and relative to individual standard BCVA.
Fourteen achromats (mean ± SD: 37.9 ± 17.6 years) and 14 normally sighted controls (mean ± SD: 25.2 ± 2.8 years) were included in the study. Without filter glasses, achromats' BCVA was best at 30 cd/m2 (mean ± SEM: 0.76 ± 0.046 logarithm of the minimum angle of resolution [logMAR], contrast = 89%) and worst at 10,000 cd/m2 (mean ± SEM: 1.41 ± 0.08 logMAR, contrast = 18%), a deterioration up to 0.6 logMAR due to increased luminance and decreased contrast. Filter glasses improved achromats' BCVA for almost all luminances by about 0.2 logMAR but lowered controls' BCVA by about 0.1 logMAR.
The VA-CAL test provides numerical proof that short-wavelength cutoff filter glasses can help patients with achromatopsia in everyday life, avoiding the common situation of severe visual impairment at certain daily object contrasts and ambient luminances.
The VA-CAL test discovers losses of spatial resolution in the visual acuity space not seen in standardized BCVA assessment. Filter glasses improve the patients' daily visual performance, rendering them a strongly recommended visual aid in achromatopsia.
定量比较色盲患者与正常人在日常环境中典型对比度和亮度组合下的视觉表现，并测量色盲患者使用短波截止滤光镜减少眩光感的有益效果。
使用自动设备（VA-CAL 测试）进行 Landolt 环最佳矫正视力（BCVA）测试。为每位参与者评估了有和没有滤光镜（透过率>550nm）时的视力空间，在 46 个对比度-亮度组合（18%-95%；0-10,000cd/m2）下进行测试。计算了两种情况下的 BCVA 差值，分别为绝对值和相对于个体标准 BCVA 的相对值。
14 名色盲患者（平均±标准差：37.9±17.6 岁）和 14 名正常视力对照者（平均±标准差：25.2±2.8 岁）纳入研究。不戴滤光镜时，色盲患者的最佳 BCVA 在 30cd/m2（平均±SEM：0.76±0.046 最小分辨角对数[logMAR]，对比度=89%），最差在 10,000cd/m2（平均±SEM：1.41±0.08 logMAR，对比度=18%），由于亮度增加和对比度降低，视力下降高达 0.6 logMAR。滤光镜几乎改善了所有亮度下色盲患者的 BCVA，提高了约 0.2 logMAR，但降低了对照组的 BCVA，降低了约 0.1 logMAR。
VA-CAL 测试提供了数字证据，证明短波截止滤光镜可以帮助色盲患者在日常生活中避免在某些日常物体对比度和环境亮度下出现严重视力障碍的常见情况。
翻译准确流畅，用词符合中文表达习惯，信息完整。
