Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, 400030, China.
JinFeng Laboratory, Chongqing, 401329, China.
Apoptosis. 2023 Oct;28(9-10):1285-1303. doi: 10.1007/s10495-023-01869-7. Epub 2023 Jun 26.
Cerebral ischemia/reperfusion (I/R) injury can result in different levels of cerebral impairment, and in severe cases, death. Curcumin, an essential bioactive component of turmeric, has a rich history as a traditional medicine for various ailments in numerous countries. Experimental and clinical research has established that curcumin offers a protective effect against cerebral I/R injury. Curcumin exerts its protective effects by acting on specific mechanisms such as antioxidant, anti-inflammatory, inhibition of ferroptosis and pyroptosis, protection of mitochondrial function and structure, reduction of excessive autophagy, and improvement of endoplasmic reticulum (ER) stress, which ultimately help to preserve the blood-brain barrier (BBB) and reducing apoptosis. There is currently a shortage of drugs undergoing clinical trials for the treatment of cerebral I/R injury, highlighting the pressing need for research and development of novel treatments to address this injury. The primary objective of this study is to establish a theoretical basis for future clinical applications of curcumin by delineating the mechanisms and protective effects of curcumin against cerebral I/R injury. Adapted with permission from [1].
脑缺血/再灌注（I/R）损伤可导致不同程度的脑损伤，在严重情况下可导致死亡。姜黄素是姜黄的一种重要生物活性成分，在许多国家，它作为传统药物被广泛用于治疗各种疾病。实验和临床研究已经证实，姜黄素对脑 I/R 损伤具有保护作用。姜黄素通过作用于特定机制发挥其保护作用，如抗氧化、抗炎、抑制铁死亡和细胞焦亡、保护线粒体功能和结构、减少过度自噬以及改善内质网（ER）应激，从而有助于保护血脑屏障（BBB）并减少细胞凋亡。目前，临床上用于治疗脑 I/R 损伤的药物短缺，这凸显了迫切需要研究和开发新的治疗方法来解决这种损伤。本研究的主要目的是通过阐述姜黄素对脑 I/R 损伤的作用机制和保护作用，为姜黄素的未来临床应用奠定理论基础。改编自[1]。
