Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
Mol Neurobiol. 2019 Feb;56(2):1391-1404. doi: 10.1007/s12035-018-1169-7. Epub 2018 Jun 9.
Ischemia-reperfusion injury (I/R injury) is a common feature of ischemic stroke which occurs when blood supply is restored after a period of ischemia. Although stroke is an important cause of death in the world, effective therapeutic strategies aiming at improving neurological outcomes in this disease are lacking. Various studies have suggested the involvement of different mechanisms in the pathogenesis of I/R injury in the nervous system. These mechanisms include oxidative stress, platelet adhesion and aggregation, leukocyte infiltration, complement activation, blood-brain barrier (BBB) disruption, and mitochondria-mediated mechanisms. Curcumin, an active ingredient of turmeric, can affect all these pathways and exert neuroprotective activity culminating in the amelioration of I/R injury in the nervous system. In this review, we discuss the protective effects of curcumin against I/R injury in the nervous system and highlight the studies that have linked biological functions of curcumin and I/R injury improvement.
缺血再灌注损伤（I/R 损伤）是缺血后血液供应恢复时发生的缺血性脑卒中的一个常见特征。尽管卒中是世界范围内的重要死亡原因，但针对该疾病改善神经预后的有效治疗策略仍十分缺乏。多项研究表明，不同机制参与了神经系统中 I/R 损伤的发病机制。这些机制包括氧化应激、血小板黏附和聚集、白细胞浸润、补体激活、血脑屏障（BBB）破坏和线粒体介导的机制。姜黄素是姜黄的一种活性成分，可影响所有这些途径，并发挥神经保护活性，最终改善神经系统中的 I/R 损伤。在本综述中，我们讨论了姜黄素对神经系统中 I/R 损伤的保护作用，并强调了将姜黄素的生物学功能与 I/R 损伤改善联系起来的研究。
