Koiwai Akinobu, Hirota Morihisa, Matsuura Tomonori, Itoh Takehito, Kin Ryo, Katayama Tomofumi, Endo Katsuya, Takasu Atsuko, Kogure Takayuki, Murakami Kazuhiro, Satoh Kennichi
Division of Gastroenterology Tohoku Medical and Pharmaceutical University Sendai Japan.
Division of Radiology Tohoku Medical and Pharmaceutical University Sendai Japan.
JGH Open. 2023 Jun 2;7(6):445-452. doi: 10.1002/jgh3.12930. eCollection 2023 Jun.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer, partly because its early detection is difficult. This study aimed to identify computed tomography (CT) findings associated with PDAC prior to diagnosis.
Past CT images were retrospectively collected from the PDAC group ( = 54) and the control group ( = 90). The following imaging findings were compared: pancreatic mass, main pancreatic duct (MPD) dilatation with or without cutoff, cyst, chronic pancreatitis with calcification, partial parenchymal atrophy (PPA), and diffuse parenchymal atrophy (DPA). In the PDAC group, CT findings were examined during the pre-diagnostic period and 6-36 months and 36-60 months before diagnosis. Multivariate analyses were performed using logistic regression.
MPD dilatation with cutoff ( < 0.0001) and PPA ( = 0.023) were identified as significant imaging findings 6-36 months before diagnosis. DPA was identified as a novel imaging finding at 6-36 months ( = 0.003) and 36-60 months ( = 0.009) before diagnosis.
DPA, MPD dilatation with cutoff, and PPA were identified as imaging findings associated with pre-diagnostic PDAC.
胰腺导管腺癌（PDAC）是一种致命性癌症，部分原因是其早期检测困难。本研究旨在确定诊断前与PDAC相关的计算机断层扫描（CT）表现。
回顾性收集PDAC组（n = 54）和对照组（n = 90）过去的CT图像。比较以下影像学表现：胰腺肿块、主胰管（MPD）扩张伴或不伴截断、囊肿、伴有钙化的慢性胰腺炎、部分实质萎缩（PPA）和弥漫性实质萎缩（DPA）。在PDAC组中，在诊断前时期以及诊断前6 - 36个月和36 - 60个月检查CT表现。使用逻辑回归进行多变量分析。
截断性MPD扩张（P < 0.0001）和PPA（P = 0.023）被确定为诊断前6 - 36个月的重要影像学表现。DPA被确定为诊断前6 - 36个月（P = 0.003）和36 - 60个月（P = 0.009）的一种新的影像学表现。
DPA、截断性MPD扩张和PPA被确定为与诊断前PDAC相关的影像学表现。
