Rysmendiev A Zh, Tukesheva B Sh, Grabarova I P, Iskakov K M
Kardiologiia. 1986 May;26(5):37-40.
The pattern of variation in primary and end products of erythrocyte lipid peroxidation (LPO) was examined in 131 patients with acute myocardial infarction. The levels of LPO products were found to be increased dramatically, the magnitude and duration of the increase being dependent on the severity of cardiogenic shock complicating myocardial infarction. The changes were particularly marked in true cardiogenic shock. The level of LPO products fell significantly on day 2-3 of myocardial infarction where it stabilized until the end of the study in patients with uncomplicated infarction treated with alpha-tocopherol acetate in addition to a symptomatic therapy. This pattern is attributed to an inhibitory effect this antioxidant may have on LPO.
对131例急性心肌梗死患者红细胞脂质过氧化（LPO）的初级和终产物的变化模式进行了研究。发现LPO产物水平显著升高，升高的幅度和持续时间取决于并发心肌梗死的心源性休克的严重程度。这些变化在真正的心源性休克中尤为明显。在心肌梗死第2 - 3天，LPO产物水平显著下降，对于除对症治疗外还接受醋酸α-生育酚治疗的无并发症梗死患者，该水平一直稳定到研究结束。这种模式归因于这种抗氧化剂可能对LPO具有的抑制作用。
