Ravelo Marrero Alejandro José, Guillén Astete Carlos Antonio, Román Miriam Menacho, Coronado Marta Rosillo, Del Rey Sánchez José Manuel, Lozano Ana Gómez, Terán Tinedo María Andreína, Díaz Mónica Vázquez, Gómez Ignacio Arribas
Clinical Chemist, Hospital Ramón y Cajal, Madrid, Spain.
Rheumatologist, Hospital Ramón y Cajal, Madrid, Spain.
Adv Lab Med. 2022 Jan 5;3(1):51-66. doi: 10.1515/almed-2021-0078. eCollection 2022 Mar.
We evaluated the prevalence of 25-hydroxyvitamin D (25-(OH)D) deficiency in our setting according to season, sex, and age. We also studied the association with parathyroid hormone (PTH) levels.
The study population comprised all patients with requests for assessment of 25-(OH)D between January 1 and December 31, 2018, as registered in the database of the laboratory information system. Major exclusion criteria were pediatric samples (<18 years) and factors affecting 25-(OH)D and/or PTH levels (i.e., kidney injury, liver disease, PTH disorders).
Among 33,601 patients (24,028 women, 9,573 men), the prevalence of 25-(OH)D deficiency was 48%. Prevalence was greater in males than in females (53% vs. 46%). By age group, deficiency was more prevalent in quartile 1 (Q1, 74-87 years) and less prevalent in quartile 2 (Q2, 60-73 years). By season, deficiency was greater in spring (nonsignificant differences with respect to winter) and lower in summer. The association between 25-(OH)D and PTH was assessed in 9,368 persons. Linear regression analysis showed a weak association (coefficient - 0.303). Multiple logistic regression analysis revealed a significant association between 25-(OH)D deficiency and increased PTH (Odds ratio (OR), 1.63). Other risk factors for increased PTH include female sex (OR, 1.27), season (winter, OR 1.63, spring OR 1.16), and age (quartile 1, OR, 3).
The prevalence of 25-(OH)D deficiency differed according to sex, age, and season of the year. Furthermore, elevation of PTH is mainly influenced by low 25-(OH)D, female sex, season, and age.
我们根据季节、性别和年龄评估了我院25-羟维生素D（25-(OH)D）缺乏症的患病率。我们还研究了其与甲状旁腺激素（PTH）水平的相关性。
研究人群包括2018年1月1日至12月31日期间在实验室信息系统数据库中登记的所有申请检测25-(OH)D的患者。主要排除标准为儿科样本（<18岁）以及影响25-(OH)D和/或PTH水平的因素（即肾损伤、肝病、PTH紊乱）。
在33601例患者中（24028例女性，9573例男性），25-(OH)D缺乏症的患病率为48%。男性患病率高于女性（53%对46%）。按年龄组划分，缺乏症在第1四分位数组（Q1，74 - 87岁）中更为普遍，在第2四分位数组（Q2，60 - 73岁）中不太普遍。按季节划分，春季缺乏症更为严重（与冬季无显著差异），夏季较低。对9368人评估了25-(OH)D与PTH之间的关联。线性回归分析显示关联较弱（系数 - 0.303）。多因素logistic回归分析显示25-(OH)D缺乏症与PTH升高之间存在显著关联（优势比（OR），1.63）。PTH升高的其他危险因素包括女性性别（OR，1.27）、季节（冬季，OR 1.63，春季OR 1.16）和年龄（第1四分位数组，OR，3）。
25-(OH)D缺乏症的患病率因性别、年龄和一年中的季节而异。此外，PTH升高主要受低25-(OH)D、女性性别、季节和年龄的影响。
