Department of Endocrinology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Obstetrics and Gynaecology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
PeerJ. 2022 Dec 16;10:e14570. doi: 10.7717/peerj.14570. eCollection 2022.
To analyze the clinical characteristics and immune function parameters and to explore the effect of hyperglycemia on the immune function in patients with Corona Virus Disease 2019 (COVID-19) with type 2 diabetes mellitus (T2DM).
This retrospective study included patients with COVID-19 with T2DM hospitalized in Renmin Hospital of Wuhan University between January 31, 2020, and February 10, 2020. The clinical data were collected and patients were divided into a well-controlled group (blood glucose 3.9-10.0 mmol/L) and a poorly-controlled group (blood glucose >10.0 mmol/L). The differences in routine blood tests, peripheral lymphocyte subsets, humoral immune components, C-reactive protein (CRP) level, and cytokines were compared, and the correlation between blood glucose and immune parameters as well as the severity of the disease was analyzed.
A total of 65 patients with COVID-19 and T2DM were included in the final analysis. Compared with the well-controlled group, patients in the poorly-controlled group had decreased lymphocytes, CD16 56 NK cells, CD3 T cells, CD8 T cells and increased neutrophil percentage, IL-6 levels, CRP levels and serum concentration of IgA. Blood glucose was inversely correlated with CD16 56 NK cells, CD3 T cells, CD4 T cells, and CD8 T cells and positively correlated with IL-6 and CRP levels. There was a positive correlation between blood glucose and the severity of the COVID-19.
Hyperglycemia will aggravate the immune dysfunction of COVID-19 patients with T2DM and affect the severity of COVID-19.
分析 2 型糖尿病合并 2019 年冠状病毒病（COVID-19）患者的临床特征和免疫功能参数，并探讨高血糖对 COVID-19 合并 2 型糖尿病患者免疫功能的影响。
本回顾性研究纳入 2020 年 1 月 31 日至 2 月 10 日期间在武汉大学人民医院住院的 COVID-19 合并 2 型糖尿病患者。收集临床资料，根据血糖控制情况将患者分为血糖控制良好组（血糖 3.9-10.0mmol/L）和血糖控制不佳组（血糖>10.0mmol/L）。比较两组血常规、外周血淋巴细胞亚群、体液免疫成分、C 反应蛋白（CRP）水平和细胞因子的差异，分析血糖与免疫参数及疾病严重程度的相关性。
最终纳入 65 例 COVID-19 合并 2 型糖尿病患者，其中血糖控制不佳组患者的淋巴细胞、CD16 56 NK 细胞、CD3 T 细胞、CD8 T 细胞减少，中性粒细胞百分比、IL-6 水平、CRP 水平和血清 IgA 浓度升高。血糖与 CD16 56 NK 细胞、CD3 T 细胞、CD4 T 细胞、CD8 T 细胞呈负相关，与 IL-6 和 CRP 水平呈正相关。血糖与 COVID-19 严重程度呈正相关。
高血糖会加重 COVID-19 合并 2 型糖尿病患者的免疫功能障碍，影响 COVID-19 的严重程度。
