The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, China.
J Diabetes Res. 2021 Jan 2;2021:9526701. doi: 10.1155/2021/9526701. eCollection 2021.
The induction of inflammation and cytokine storm was proposed to play a critical role in COVID-19. This study is aimed at investigating the relationship between glucose metabolism and the inflammatory state of inpatients with COVID-19. 71 inpatients with COVID-19 were classified into nondiabetes mellitus (NDM) group, impaired fasting glucose (IFG) group, and diabetes mellitus (DM) group. The average hospitalization days were significantly shorter in DM patients when compared with patients in the IFG group and NDM group. CD4 T cell percentage was higher while CD8 T cells percentage was lower in the DM group than those in the NDM group. The serum levels of IL-6, IL-2, IL-10, and INF- in the DM group were upregulated when compared with those in the NDM group. The serum levels of TNF-, IL-4, IL-2, IL-10, and INF- were significantly higher in the DM group than those in the IFG group. A significant difference was observed in CD4 T cell, CD4/CD8 ratio percentage, IL-6, and IL-10 between the NDM group and DM group with adjusted BMI. In conclusion, COVID-19 patients with elevated glucose levels have promoted cytokine profiles and immune response.
炎症和细胞因子风暴的诱导被认为在 COVID-19 中发挥关键作用。本研究旨在探讨 COVID-19 住院患者葡萄糖代谢与炎症状态之间的关系。71 例 COVID-19 住院患者分为非糖尿病（NDM）组、空腹血糖受损（IFG）组和糖尿病（DM）组。与 IFG 组和 NDM 组相比，DM 组患者的平均住院天数明显缩短。DM 组 CD4 T 细胞百分比高于 NDM 组，CD8 T 细胞百分比低于 NDM 组。与 NDM 组相比，DM 组血清中 IL-6、IL-2、IL-10 和 INF-的水平上调。与 IFG 组相比，DM 组血清中 TNF-α、IL-4、IL-2、IL-10 和 INF-的水平显著升高。在调整 BMI 后，NDM 组和 DM 组之间的 CD4 T 细胞、CD4/CD8 比值百分比、IL-6 和 IL-10 存在显著差异。结论：血糖水平升高的 COVID-19 患者具有促进细胞因子谱和免疫反应的特征。
