结肠腺癌中PBX家族与免疫浸润及药物敏感性的相关性分析

Correlation analysis of PBX family with immune invasion and drug sensitivity in colon adenocarcinoma.

作者信息

Chao Guanqun, Zhang Lan

机构信息

Department of General Practice, Sir Run Run Shaw Hospital, Zhejiang University, China.

出版信息

Heliyon. 2023 Jun 13;9(6):e17220. doi: 10.1016/j.heliyon.2023.e17220. eCollection 2023 Jun.

DOI:10.1016/j.heliyon.2023.e17220

PMID:37360109

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10285256/

Abstract

OBJEDTIVE

Pre-B cell leukemia (PBX) has been found to be associated with cancer, but poorly studied with colon adenocarcinoma (COAD). In this study, the correlation between PBX family and COAD pathogenesis and immune cytokine infiltration was further explored by analyzing online tumor databases, in order to find new biomarkers for the diagnosis of COAD.

METHODS

The online database was used to analyze gene differential expression, methylation level, gene mutation rate, immune infiltration difference, drug sensitivity, and so on.

RESULTS

PBX1 and PBX3 decreased in COAD. PBX2 and PBX4 increased. The expression of PBX1 and PBX2 in different clinical stages was different. PBX4 was valuable for the prognosis of COAD. PBX family has correlation between COAD and immune infiltration. PBX2 was correlated with different pathological stages. PBX3 had the highest gene mutation rate, followed by PBX1, PBX2 and PBX4. PBX1, PBX2 and PBX4 were correlated with the sensitivity of multiple drugs.

CONCLUSION

The PBX family is differentially expressed in COAD and has a genetic mutation, and its protein network is closely related to the HOX family and is associated with immune infiltration of COAD.

摘要

目的

已发现前B细胞白血病（PBX）与癌症相关，但对其与结肠腺癌（COAD）的研究较少。本研究通过分析在线肿瘤数据库，进一步探讨PBX家族与COAD发病机制及免疫细胞因子浸润之间的相关性，以寻找COAD诊断的新生物标志物。

方法

利用在线数据库分析基因差异表达、甲基化水平、基因突变率、免疫浸润差异、药物敏感性等。

结果

PBX1和PBX3在COAD中表达降低，PBX2和PBX4表达升高。PBX1和PBX2在不同临床分期的表达不同。PBX4对COAD的预后有价值。PBX家族与COAD和免疫浸润之间存在相关性。PBX2与不同病理分期相关。PBX3的基因突变率最高，其次是PBX1、PBX2和PBX4。PBX1、PBX2和PBX4与多种药物的敏感性相关。