Moosa H H, Makaroun M S, Peitzman A B, Steed D L, Webster M W
J Surg Res. 1986 May;40(5):482-7. doi: 10.1016/0022-4804(86)90219-2.
Transcutaneous oxygen tension (TcPO2) is determined by blood flow and arterial oxygen tension (PaO2) and has been advocated as a measurement of tissue perfusion in peripheral vascular disease. The purpose of this study was to define the relationship between regional blood flow, PaO2, and TcPO2. TcPO2 sensors were placed on the skin of the anterior tibial regions of the hind limbs of 15 dogs. After occluding collateral blood flow, an external flow probe was placed around the femoral artery and an adjustable clamp was used to produce graded ischemia. Progressive reductions in blood flow were correlated with TcPO2 values at inspired oxygen concentrations (FiO2) of 0.21, 0.50, and 1.00. TcPO2 measured at room air decreased nonlinearly in relation to flow with a marked drop occurring below 20% of baseline flow. TcPO2 measured at increased FiO2 was dependent primarily on PaO2 at flow rates greater than 50% of baseline. With reduction in flow below 25% of baseline, TcPO2 was dependent solely on flow and was not augmented by increases in PaO2. The data suggest that TcPO2 can accurately reflect changes in blood flow to an extremity when flow is severely restricted.
经皮氧分压（TcPO2）由血流和动脉氧分压（PaO2）决定，已被提倡作为外周血管疾病中组织灌注的一种测量方法。本研究的目的是确定局部血流、PaO2和TcPO2之间的关系。将TcPO2传感器置于15只犬后肢胫前区域的皮肤上。在阻断侧支血流后，将一个外部血流探头置于股动脉周围，并使用一个可调节的夹子产生分级缺血。在吸入氧浓度（FiO2）为0.21、0.50和1.00时，血流的逐渐减少与TcPO2值相关。在室内空气中测量的TcPO2与血流呈非线性下降，在低于基线血流的20%时出现明显下降。在增加FiO2时测量的TcPO2在流速大于基线的50%时主要取决于PaO2。当血流减少到低于基线的25%时，TcPO2仅取决于血流，且不会因PaO2的增加而增加。数据表明，当血流严重受限 时，TcPO2可以准确反映肢体血流的变化。
