新型吡非尼酮衍生物：合成与生物学评价
Novel pirfenidone derivatives: synthesis and biological evaluation.
作者信息
Yao Maoling, Sun Maoru, Chen Congdi, Jin Liming, Yang Hongjun, Li Yong, Yin Shufan
机构信息
Key Laboratory of General Chemistry of the National Ethnic Affairs Commission, School of Chemistry and Environment, Southwest Minzu University Chengdu 610041 China
College of Chemistry and Life Science, Chengdu Normal University Chengdu 611130 China.
出版信息
RSC Med Chem. 2023 May 19;14(6):1158-1164. doi: 10.1039/d3md00072a. eCollection 2023 Jun 22.
Abstract
In order to discover novel anti-pulmonary fibrosis agents, a series of novel pirfenidone derivatives were designed and synthesized. All compounds were investigated for their anti-pulmonary activity and characterized by C and H nuclear magnetic resonance and high-resolution mass spectrometry. Preliminary studies on their biological activity showed that all target compounds showed different degrees of inhibition on pulmonary fibrosis, and most of the derivatives were significantly better than pirfenidone.
摘要
为了发现新型抗肺纤维化药物，设计并合成了一系列新型吡非尼酮衍生物。对所有化合物进行了抗肺活性研究，并通过碳氢核磁共振和高分辨率质谱进行了表征。对其生物活性的初步研究表明，所有目标化合物对肺纤维化均表现出不同程度的抑制作用，且大多数衍生物的效果明显优于吡非尼酮。
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