用于增强光动力疗法的长波长吸收苯并咪唑二氢卟酚
Long-Wavelength Absorbing Benzimidazolo-Chlorin for Enhanced Photodynamic Therapy.
作者信息
Wu Huiqiang, Yeo Sooho, Li Jiazhu, Wang Jinjun, Lee Woo Kyoung, Yoon Il
机构信息
Center for Nano Manufacturing and Department of Nanoscience and Engineering, Inje University, 197 Injero, Gimhae, Gyeongnam 50834, Republic of Korea.
College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005, China.
出版信息
ACS Omega. 2023 Jun 6;8(24):21941-21947. doi: 10.1021/acsomega.3c01807. eCollection 2023 Jun 20.
In this study, we condensed methyl pyropheophorbide-a () with 1,2-phenylenediamine to synthesize benzimidazolo-chlorin () as an effective near-infrared photosensitizer (PS) with an absorption maximum of 730 nm. The ability of to generate singlet oxygen, as well as its photodynamic effect on A549 and HeLa cells, was investigated. PS exhibited strong phototoxicity and negligible dark toxicity. Its structure was examined by UV-visible spectroscopy, nuclear magnetic resonance, and high-resolution fast atom bombardment mass spectrometry.
在本研究中，我们将焦脱镁叶绿酸-a甲酯（）与1,2-苯二胺缩合，合成了苯并咪唑并二氢卟吩（）作为一种有效的近红外光敏剂（PS），其最大吸收波长为730 nm。研究了其产生单线态氧的能力及其对A549和HeLa细胞的光动力效应。PS表现出强烈的光毒性和可忽略不计的暗毒性。通过紫外可见光谱、核磁共振和高分辨率快原子轰击质谱对其结构进行了研究。
Zotero 插件