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用于提高光动力疗法抗癌效率的紫红素 - 18 负载固体脂质纳米粒的合成与设计

Synthesis and Design of Purpurin-18-Loaded Solid Lipid Nanoparticles for Improved Anticancer Efficiency of Photodynamic Therapy.

作者信息

Yeo Sooho, Song Hyeon Ho, Kim Min Je, Hong Seokhyeon, Yoon Il, Lee Woo Kyoung

机构信息

Center for Nano Manufacturing, Department of Nanoscience and Engineering, Inje University, Gimhae 50834, Korea.

出版信息

Pharmaceutics. 2022 May 15;14(5):1064. doi: 10.3390/pharmaceutics14051064.

DOI:10.3390/pharmaceutics14051064
PMID:35631650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9146874/
Abstract

Purpurin-18 (P18) is one of the essential photosensitizers used in photodynamic therapy (PDT), but its hydrophobicity causes easy coalescence and poor bioavailability. This study aimed to synthesize P18 and design P18-loaded solid lipid nanoparticles (SLNs) to improve its bioavailability. The characteristics of the synthesized P18 and SLNs were evaluated by particle characteristics and release studies. The effects of P18 were evaluated using the 1,3-diphenylisobenzofuran (DPBF) assay as a nonbiological assay and a phototoxicity assay against HeLa and A549 cell lines as a biological assay. The mean particle size and zeta potential of the SLNs were 164.70-762.53 nm and -16.77-25.54 mV, respectively. These results indicate that P18-loaded SLNs are suitable for an enhanced permeability and retention effect as a passive targeting anti-cancer strategy. The formulations exhibited a burst and sustained release based on their stability. The DPBF assay indicated that the PDT effect of P18 improved when it was entrapped in the SLNs. The photocytotoxicity assay indicated that P18-loaded SLNs possessed light cytotoxicity but no dark cytotoxicity. In addition, the PDT activity of the formulations was cell type- and size-dependent. These results suggest that the designed P18-loaded SLNs are a promising tool for anticancer treatment using PDT.

摘要

紫红素 -18（P18）是光动力疗法（PDT）中使用的重要光敏剂之一，但其疏水性导致容易聚结且生物利用度差。本研究旨在合成P18并设计负载P18的固体脂质纳米粒（SLN）以提高其生物利用度。通过颗粒特性和释放研究评估合成的P18和SLN的特性。使用1,3 - 二苯基异苯并呋喃（DPBF）测定作为非生物学测定以及针对HeLa和A549细胞系的光毒性测定作为生物学测定来评估P18的效果。SLN的平均粒径和zeta电位分别为164.70 - 762.53 nm和 - 16.77 - 25.54 mV。这些结果表明，负载P18的SLN作为一种被动靶向抗癌策略适用于增强的渗透和滞留效应。基于其稳定性，制剂表现出突释和缓释。DPBF测定表明，当P18包封在SLN中时其PDT效果得到改善。光细胞毒性测定表明，负载P18的SLN具有光细胞毒性但无暗细胞毒性。此外，制剂的PDT活性具有细胞类型和尺寸依赖性。这些结果表明，所设计的负载P18的SLN是使用PDT进行抗癌治疗的有前景的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/a5e3852c33d4/pharmaceutics-14-01064-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/a9c23f8f46ca/pharmaceutics-14-01064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/62e829d8975c/pharmaceutics-14-01064-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/0661f403694f/pharmaceutics-14-01064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/16e4e5549972/pharmaceutics-14-01064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/65d45d4bfbd9/pharmaceutics-14-01064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/1da14bd2e1b2/pharmaceutics-14-01064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/482a525b30b9/pharmaceutics-14-01064-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/ee182e5c128f/pharmaceutics-14-01064-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/372f1eb2705b/pharmaceutics-14-01064-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/a5e3852c33d4/pharmaceutics-14-01064-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/a9c23f8f46ca/pharmaceutics-14-01064-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/62e829d8975c/pharmaceutics-14-01064-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/0661f403694f/pharmaceutics-14-01064-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/16e4e5549972/pharmaceutics-14-01064-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/65d45d4bfbd9/pharmaceutics-14-01064-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/1da14bd2e1b2/pharmaceutics-14-01064-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/482a525b30b9/pharmaceutics-14-01064-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/ee182e5c128f/pharmaceutics-14-01064-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/372f1eb2705b/pharmaceutics-14-01064-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ecd6/9146874/a5e3852c33d4/pharmaceutics-14-01064-g010.jpg

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1
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2
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RSC Adv. 2020 Jul 17;10(45):26777-26791. doi: 10.1039/d0ra03491f. eCollection 2020 Jul 15.
3
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Nanomaterials (Basel). 2024 Sep 26;14(19):1557. doi: 10.3390/nano14191557.
4
Hydrophilic Biocompatible Fluorescent Organic Nanoparticles as Nanocarriers for Biosourced Photosensitizers for Photodynamic Therapy.亲水性生物相容性荧光有机纳米颗粒作为用于光动力疗法的生物源光敏剂的纳米载体
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5
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