Cohen R C, Filler R M, Konuma K, Bahoric A, Kent G, Smith C
J Thorac Cardiovasc Surg. 1986 Aug;92(2):296-304.
Stenosis of 50% to 80% of the cervical or thoracic tracheal lumen was created in 17 piglets by encircling the trachea with silicone rubber sheet for 3 to 19 days (median 14 days). In 13 animals thoracic tracheal stenosis was repaired by longitudinal incision and insertion of a free tibial periosteal graft into the defect. An omental pedicle graft was applied to the surface of the free periosteal graft to augment its blood supply in three of these animals. An endotracheal silicone rubber splint was left in place for 2 to 3 weeks after the operations. Four animals served as untreated controls. In 12 of 13 piglets respiratory obstruction was relieved. One repair failed because of graft necrosis. In two animals put to death 1 month and 2 months later, stenosis was absent and the grafts showed variable ossification. The luminal surface had epithelialized. In nine of 10 animals put to death 3 months after the operation, tracheal cross-sectional areas had doubled, stenosis and granulation tissue were absent, and all the grafts had ossified and epithelialized. A mild stenosis (24%) developed over a 2 mm length in one animal and the graft had not ossified. The omental pedicle graft did not improve vascularization of the free periosteal graft. These studies describe a model of tracheal stenosis that can be used to assess various methods of repair. The results indicate that tracheal stenosis can be successfully treated by incision and insertion of a free periosteal graft into the defect.
通过用硅橡胶片环绕气管3至19天（中位数为14天），在17只仔猪中造成颈段或胸段气管管腔50%至80%的狭窄。在13只动物中，通过纵向切口并将游离的胫骨骨膜移植物插入缺损处来修复胸段气管狭窄。在其中3只动物中，将带蒂大网膜移植物应用于游离骨膜移植物表面以增加其血供。术后气管内留置硅橡胶夹板2至3周。4只动物作为未治疗的对照。13只仔猪中有12只的呼吸阻塞得到缓解。1例修复因移植物坏死而失败。在术后1个月和2个月处死的2只动物中，无狭窄，移植物显示不同程度的骨化。管腔表面已上皮化。在术后3个月处死的10只动物中有9只，气管横截面积增加了一倍，无狭窄和肉芽组织，所有移植物均已骨化并上皮化。1只动物在2mm长度上出现轻度狭窄（24%），移植物未骨化。带蒂大网膜移植物未改善游离骨膜移植物的血管化。这些研究描述了一种可用于评估各种修复方法的气管狭窄模型。结果表明，通过切口并将游离骨膜移植物插入缺损处可成功治疗气管狭窄。
