Dykes E H, Bahoric A, Smith C, Kent G, Filler R M
Department of Surgery, Hospital For Sick Children, Toronto, Ontario, Canada.
J Pediatr Surg. 1990 Jan;25(1):25-9. doi: 10.1016/s0022-3468(05)80158-7.
Four groups of piglets were used to test the use of pericardium and periosteum as free grafts in the repair of full thickness cervical tracheal defects. Pericardium provided an airtight, rapidly healing graft, but did not give sufficient structural rigidity to prevent narrowing and growth failure at the graft site. Composite grafts of pericardium and periosteum were also unsatisfactory, in that the periosteum failed to produce enough bone to prevent collapse of the graft. Since previous studies have shown that periosteal grafts result in good bone formation when applied alone or as an extramucosal support, it is concluded that the osteogenic potential is dependent on the available blood supply and speed of revascularization. It appears that the presence of pericardium in the composite grafts may have inhibited this property.
使用四组仔猪来测试心包和骨膜作为游离移植物在修复全层颈段气管缺损中的应用。心包提供了一个气密且愈合迅速的移植物，但没有给予足够的结构刚性来防止移植物部位的狭窄和生长失败。心包和骨膜的复合移植物也不令人满意，因为骨膜未能产生足够的骨来防止移植物塌陷。由于先前的研究表明，单独应用骨膜移植物或作为黏膜外支撑时会导致良好的骨形成，因此得出结论，成骨潜能取决于可用的血液供应和血管再生速度。似乎复合移植物中心包的存在可能抑制了这种特性。
