Nagasawa H, Sakurai N
Life Sci. 1986 Jul 28;39(4):351-7. doi: 10.1016/0024-3205(86)90653-3.
Normal mammary gland growth and reproduction were examined in C3H/HeMei mice given caffeine as drinking water (500 mg/l tap water) after weaning on day 20 of age. Caffeine ingestion had little effects on any of the day of vaginal opening, body growth, pattern of estrous cycles, mammary gland growth and reproduction except for the rearing rate on day 12 of lactation. Five out of 12 mothers given caffeine lost all pups before day 12 and resulted in 51% of the rearing rate on that day, while that of the control was 91%. The rate did not change thereafter in either group. The results indicate that the chronic heavy ingestion of caffeine would induce the high mortality of pups during early stage of lactation.
在20日龄断奶后，给C3H/HeMei小鼠提供含咖啡因的饮用水（500毫克/升自来水），以此来研究正常乳腺的生长和繁殖情况。除了哺乳期第12天的育成率外，摄入咖啡因对阴道开口日、身体生长、发情周期模式、乳腺生长和繁殖均无显著影响。在12只摄入咖啡因的母鼠中，有5只在第12天前失去了所有幼崽，导致当日育成率为51%，而对照组为91%。此后两组的育成率均未发生变化。结果表明，长期大量摄入咖啡因会导致哺乳期早期幼崽的高死亡率。
