Lukman Kiki, Mulyawan Andi, Nugrahani Annisa Dewi, Rudiman Reno, Primastari Etis
Departments of Surgery.
Obstetrics and Gynaecology.
Ann Med Surg (Lond). 2023 May 3;85(6):2496-2501. doi: 10.1097/MS9.0000000000000757. eCollection 2023 Jun.
Early-onset colorectal cancer (CRC) has different clinical and pathological characteristics compared with late-onset CRC. Mortality rate as a postoperative outcome is a patient's postoperative outcome considered based on the state of life or death. The objective of this research is to analyse the comparison between clinicopathological aspect of early-onset vs. late-onset CRC as well as their correlation with the mortality rate in Indonesia to support global data.
The authors performed a case-control study on 170 subjects with CRC from November 2021 to November 2022 in a Tertiary Hospital in Bandung. Data were extracted from electronic medical records CRC Registry. Bivariate and correlation analyses were used to analyse the difference between variables using IBM SPSS 24.0. less than 0.05 was considered statistically significant.
Anaemia and tumour location variables were significantly different in the early-onset group compared with the late-onset group (<0.001). It was also found that anaemia (<0.001), pathological features (<0.001), and tumour location (=0.013) had significantly low correlation with onset of CRC (r=0.325; r=0.397; r=0.342, respectively).
There is no statistically significant correlation between the clinicopathological features of CRC in both onset and mortality rates in this study.
早发性结直肠癌(CRC)与晚发性结直肠癌相比具有不同的临床和病理特征。作为术后结果的死亡率是根据患者的生死状况来考虑的术后结果。本研究的目的是分析印度尼西亚早发性与晚发性结直肠癌的临床病理方面的比较及其与死亡率的相关性,以支持全球数据。
作者于2021年11月至2022年11月在万隆的一家三级医院对170例结直肠癌患者进行了病例对照研究。数据从电子病历结直肠癌登记处提取。使用IBM SPSS 24.0进行双变量和相关性分析以分析变量之间的差异。P值小于0.05被认为具有统计学意义。
早发性组与晚发性组相比,贫血和肿瘤位置变量存在显著差异(<0.001)。还发现贫血(<0.001)、病理特征(<0.001)和肿瘤位置(=0.013)与结直肠癌的发病有显著低相关性(r分别为0.325;0.397;0.342)。
本研究中,结直肠癌的临床病理特征与发病率和死亡率之间无统计学显著相关性。