Gerber M A, Thung S N, Bodenheimer H C, Kapelman B, Schaffner F
Liver. 1986 Apr;6(2):85-8. doi: 10.1111/j.1600-0676.1986.tb00273.x.
More than 25% of undirected percutaneous liver needle biopsies that are performed in search of metastatic neoplasms yield false negative specimens. Often, however, histologic changes are observed in the liver adjacent to space-occupying lesions due to focal obstruction of bile and blood flow. These alterations were defined by semi-quantitative evaluation of 20 liver biopsy specimens with metastatic neoplasms, and revealed a characteristic histologic triad consisting of proliferated and abnormal bile ductules, polymorphonuclear leukocytes in edematous portal tracts and focal sinusoidal dilatation. When 15 patients with this combination of histologic alterations, but without malignant cells in liver biopsy specimens, were investigated prospectively, 13 patients (87%) were found to have hepatic metastases. Therefore, the observation of the histologic triad described here should lead to a continued search for space-occupying lesions in the liver.
在寻找转移性肿瘤时进行的超过25%的非定向经皮肝穿刺活检会产生假阴性标本。然而，由于胆汁和血流的局部阻塞，在占位性病变附近的肝脏中常常可以观察到组织学变化。通过对20例有转移性肿瘤的肝活检标本进行半定量评估来定义这些改变，结果显示出一个特征性的组织学三联征，包括增生和异常的胆小管、水肿门静脉区的多形核白细胞以及局灶性肝血窦扩张。当对15例有这种组织学改变组合但肝活检标本中无恶性细胞的患者进行前瞻性研究时，发现13例患者（87%）有肝转移。因此，观察此处描述的组织学三联征应促使继续在肝脏中寻找占位性病变。
