Evaluation of A7488G polymorphism in -infected patients: a case-control study.

UNLABELLED

Interleukin 17 (IL-17) plays an important role in the inflammation of the gastric mucosa and, in severe cases, the development of gastric cancer. Thus, the authors aimed to evaluate the A7488G polymorphism in () patients.

PATIENTS AND METHODS

A total of 86 adults (in two -positive and -negative groups) were included in the study. To identify the infection, rapid urease test and polymerase chain reaction (PCR) were performed. The gene was also evaluated as a bacterial virulence factor. PCR-restriction fragment length polymorphism was used to investigate the A7488G polymorphism in gastric biopsies using the enzyme.

RESULTS

96.5% of patients in both groups did not show any mutation and had AA genotype, and only three patients infected with -carrying strains had polymorphism in the A7488G gene, which included AG (one case) and GG (two cases) patterns. No significant relationship was found between these polymorphisms in the two groups of -positive and -negative patients, while, interestingly, a significant difference was observed between the polymorphisms and the presence of the gene.

CONCLUSION

This report is one of the first to demonstrate the association of A7488G polymorphism with infection and the presence of the gene. Although no significant association between polymorphism and infection was found in the population of this study, the patients with mutated genotypes were positive for the gene, which was statistically significant. Therefore, the possibility of the role of pathogenic strains in causing mutations in cytokine genes is more conceivable.