Bird H A, Ring E F, Bacon P A
Ann Rheum Dis. 1979 Feb;38(1):36-9. doi: 10.1136/ard.38.1.36.
We have compared three intra-articular steroid preparations in a double blind study on 30 patients with rheumatoid arthritis and bilateral synovitis of the knees. One knee was injected with 1.0 ml of either prednisolone t-butyl acetate, methyl prednisolone acetate, or triamcinolone hexacetonide, and the patients were followed up for 6 weeks with regular clinical and thermographic assessments. Thermographic improvement was seen with all 3 drugs but was greatest initially and longest lasting with triamcinolone. No significant systemic improvement was seen with any drug after a single injection, though all 3 steroid preparations suppressed endogenous cortisol.
我们在一项针对30名类风湿性关节炎且双膝患有双侧滑膜炎患者的双盲研究中，比较了三种关节内注射用类固醇制剂。向一侧膝关节注射1.0毫升醋酸叔丁基泼尼松龙、醋酸甲泼尼龙或己酸曲安奈德中的一种，对患者进行为期6周的随访，并进行定期临床和热成像评估。三种药物均可见热成像改善，但曲安奈德最初改善最大且持续时间最长。单次注射后，使用任何一种药物均未观察到明显的全身改善，不过所有三种类固醇制剂均抑制了内源性皮质醇。
