Student Research Committee, Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran.
Cell Tissue Bank. 2024 Mar;25(1):195-215. doi: 10.1007/s10561-023-10099-9. Epub 2023 Jun 26.
Oxygen pressure plays an integral role in regulating various aspects of cellular biology. Cell metabolism, proliferation, morphology, senescence, metastasis, and angiogenesis are some instances that are affected by different tensions of oxygen. Hyperoxia or high oxygen concentration, enforces the production of reactive oxygen species (ROS) that disturbs physiological homeostasis, and consequently, in the absence of antioxidants, cells and tissues are directed to an undesired fate. On the other side, hypoxia or low oxygen concentration, impacts cell metabolism and fate strongly through inducing changes in the expression level of specific genes. Thus, understanding the precise mechanism and the extent of the implication of oxygen tension and ROS in biological events is crucial to maintaining the desired cell and tissue function for application in regenerative medicine strategies. Herein, a comprehensive literature review has been performed to find out the impacts of oxygen tensions on the various behaviors of cells or tissues.
氧气压力在调节细胞生物学的各个方面中起着不可或缺的作用。细胞代谢、增殖、形态、衰老、转移和血管生成等方面都会受到不同氧气张力的影响。高氧或高氧浓度会促使活性氧（ROS）的产生，从而破坏生理平衡，而在没有抗氧化剂的情况下，细胞和组织会走向不良的命运。另一方面，低氧或低氧浓度会通过诱导特定基因表达水平的变化强烈影响细胞代谢和命运。因此，了解氧气张力和 ROS 在生物事件中的精确机制和影响程度对于维持所需的细胞和组织功能以应用于再生医学策略至关重要。在此，我们进行了全面的文献综述，以了解氧气张力对细胞或组织的各种行为的影响。
