Pomarède R, Moriette G, Czernichow P, Relier J P
Arch Fr Pediatr. 1978 Dec;35(10 Suppl):75-83.
A systematic study has been undertaken to improve the understanding of water regulation in premature babies who are artificially ventilated. Thirty nine premature babies, 16 normal (Group N, GA 31.4 weeks, B/W 1622 g) and 23 with respiratory distress syndrome who were ventilated with or without continuous positive pressure (Group V, GA 31 weeks, BW 1505 g) have been studied. Plasma osmolalities were the same in both groups (284 and 282 mosM/Kg H2O) but there were significant differences (p less than 0.001) between the urine osmolalities N = 150.6 +/- 19.6 V = 294 +/- 25.9 mosM/Kg H2O) and the plasma ADH levels of the two groups (N = 2.9 +/- 0.4 pg/ml, V = 12.2 +/- 2.4 pg/ml). There was a significant correlation between the urine osmolality and the plasma ADH level but not between plasma osmolality and the plasma ADH level. Several hypotheses can be proposed but none are satisfactory.
已开展一项系统性研究，以增进对人工通气早产儿水调节的理解。研究了39名早产儿，其中16名正常（N组，孕龄31.4周，体重1622克），23名患有呼吸窘迫综合征，采用或未采用持续正压通气（V组，孕龄31周，体重1505克）。两组的血浆渗透压相同（284和282毫渗摩尔/千克水），但两组的尿渗透压（N = 150.6 +/- 19.6，V = 294 +/- 25.9毫渗摩尔/千克水）和血浆抗利尿激素水平（N = 2.9 +/- 0.4皮克/毫升，V = 12.2 +/- 2.4皮克/毫升）存在显著差异（p小于0.001）。尿渗透压与血浆抗利尿激素水平之间存在显著相关性，但血浆渗透压与血浆抗利尿激素水平之间无相关性。可以提出几种假设，但均不尽人意。
