Department of Hematology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Hematology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Cancer Med. 2023 Aug;12(15):16637-16648. doi: 10.1002/cam4.6280. Epub 2023 Jun 27.
To analyze psychological states and needs of patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Questionnaires were sent to 101 allo-HSCT survivors and 96 questionnaires were returned. The questionnaire covered several categories: (1) demographics and general information, (2) physical conditions, (3) psychologic status and sleep quality, (4) survivor's comments on transplantation, (5) demands and needs, (6) preferred forms and channels of information.
Depression and poor sleep quality were major concerns troubling allo-HSCT survivors. A notable discrepancy exists between clinically diagnosed depression (4.2%) and self- reported depression based on BDI-13 (55.2%). Young adults (18-49 years old), chronic graft-versus-host disease, the ECOG performance score of 2-4, surviving within 5 years since HSCT, no or low dose of ATG used and being single were significantly associated with self-reported depression. Based on the PSQI score, 75% of survivors experienced varying degrees of sleep quality impairment. Young adults, chronic GVHD and the ECOG score of 2-4 were significantly associated with worse sleep quality. The majority of patients reported unmet needs on physical and psychosocial aspects. Nutrition information was the most important topic, followed by disease treatments and fatigue. Differences in informational needs were found in the survivors according to age, time since HSCT and gender. WeChat public account and WeChat applet, mobile interactive platform and one-to-one conversation were the favorite channel for information.
Clinicians should establish more appropriate survivorship care plans focusing on survivors' psychologic states, demands and needs.
分析异基因造血干细胞移植（allo-HSCT）后患者的心理状态和需求。
向 101 名 allo-HSCT 幸存者发送问卷，回收了 96 份问卷。问卷涵盖了几个类别：（1）人口统计学和一般信息，（2）身体状况，（3）心理状态和睡眠质量，（4）幸存者对移植的评价，（5）需求和需求，（6）信息的首选形式和渠道。
抑郁和睡眠质量差是困扰 allo-HSCT 幸存者的主要问题。根据 BDI-13，临床上诊断的抑郁（4.2%）和自我报告的抑郁（55.2%）之间存在显著差异。年轻人（18-49 岁）、慢性移植物抗宿主病、ECOG 表现评分为 2-4、HSCT 后 5 年内存活、未使用或低剂量 ATG 以及单身与自我报告的抑郁显著相关。根据 PSQI 评分，75%的幸存者存在不同程度的睡眠质量受损。年轻人、慢性 GVHD 和 ECOG 评分为 2-4 与睡眠质量差显著相关。大多数患者报告在身体和社会心理方面存在未满足的需求。营养信息是最重要的话题，其次是疾病治疗和疲劳。根据年龄、HSCT 后时间和性别，幸存者在信息需求方面存在差异。微信公众号和小程序、移动互动平台和一对一对话是信息的首选渠道。
临床医生应制定更合适的生存护理计划，重点关注幸存者的心理状态、需求和需求。
