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坏血病:重新发现一种被遗忘的疾病。

Scurvy: Rediscovering a Forgotten Disease.

作者信息

Gandhi Mustafa, Elfeky Omar, Ertugrul Hamza, Chela Harleen Kaur, Daglilar Ebubekir

机构信息

Department of Internal Medicine, University of Missouri, Columbia, MO 65211, USA.

Department of Medicine, University of Florida, Leesburg, FL 32611, USA.

出版信息

Diseases. 2023 May 26;11(2):78. doi: 10.3390/diseases11020078.

Abstract

Scurvy is a nutritional deficiency caused by low vitamin C levels that has been described since ancient times. It leads to a varied presentation, affecting multiple organ systems due to its role in the biochemical reactions of connective tissue synthesis. Common manifestations include gingival bleeding, arthralgias, skin discoloration, impaired wound healing, perifollicular hemorrhage, and ecchymoses. Although there has been a dramatic reduction in the prevalence of scurvy in modern times owing to vitamin C supplementation and intake, sporadic cases still occur. In developed countries, it is mainly diagnosed in the elderly and malnourished individuals and is associated with alcoholism, low socio-economic status, and poor dietary habits. Scurvy has been an unusual cause of gastrointestinal (GI) bleeding among other GI manifestations. It can be adequately treated and prevented via vitamin C supplementation.

摘要

坏血病是一种由维生素C水平低下引起的营养缺乏症,自古以来就有相关描述。它会导致多种症状表现,由于其在结缔组织合成的生化反应中的作用,会影响多个器官系统。常见表现包括牙龈出血、关节痛、皮肤变色、伤口愈合受损、毛囊周围出血和瘀斑。尽管由于补充和摄入维生素C,现代社会坏血病的患病率已大幅下降,但仍有散发病例出现。在发达国家,坏血病主要在老年人和营养不良的个体中被诊断出来,并且与酗酒、社会经济地位低下和不良饮食习惯有关。坏血病一直是胃肠道(GI)出血及其他胃肠道表现的一个不常见原因。通过补充维生素C可以对其进行充分治疗和预防。

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