Yavorkovsky L L, Yavorkovsky L I, Bondare D K
Neoplasma. 1986;33(3):355-9.
A case of acute undifferentiated leukemia with a Ph1-chromosome and a typical translocation t(9;22) is reported in a 54-year-old female with Hodgkin's disease. The interval from diagnosis of Hodgkin's disease to the development of acute leukemia was 19 months. Treatment of Hodgkin's disease consisted of combined cytotoxic therapy including irradiation and chemotherapy. Detection of Ph1-chromosome in undifferentiated blasts supports the suggestion of leukemogenic chromosomal aberration within uncommitted hemopoietic cells.
报告了一例54岁患霍奇金病的女性，患有伴有Ph1染色体和典型易位t(9;22)的急性未分化白血病。从霍奇金病诊断到急性白血病发生的间隔为19个月。霍奇金病的治疗包括联合细胞毒性疗法，其中有放疗和化疗。在未分化母细胞中检测到Ph1染色体支持了未定向造血细胞内致白血病染色体畸变的观点。
