Peele D B, MacPhail R C, Farmer J D
Neurobehav Toxicol Teratol. 1986 May-Jun;8(3):273-7.
Flavor aversions induced by intraperitoneal (IP) and oral (PO) administration of thallium sulfate were compared in a repeated trial, two-bottle preference test. Male Long-Evans rats (N = 6/group) were given 30-min access to a 0.1% saccharin solution followed 20-min later by either IP or PO thallium sulfate (2.5, 5, 10 or 20 mg/kg), vehicle or nothing. Non-treated and vehicle-treated rats consistently preferred the saccharin solution, with relative saccharin intakes ranging from 0.65 to 0.85 over the three choice trials. On the first choice trial, flavor aversions produced by IP-administered thallium sulfate were marginal and occurred only at the highest dosage. In contrast, on the first choice trial, PO-administered thallium sulfate led to pronounced aversions at all but the lowest dosage. Saccharin preferences on the second and third choice trials resembled those obtained on the first choice trial. These results suggest that failure to obtain toxicant-induced flavor aversions may be due in part to the particular route by which the toxicant is administered.
在一项重复试验的双瓶偏好测试中，比较了通过腹腔注射（IP）和口服（PO）硫酸铊诱导的味觉厌恶。雄性Long-Evans大鼠（每组N = 6）可在30分钟内饮用0.1%的糖精溶液，20分钟后，腹腔注射或口服硫酸铊（2.5、5、10或20 mg/kg）、赋形剂或不做处理。未处理和接受赋形剂处理的大鼠始终偏好糖精溶液，在三次选择试验中，相对糖精摄入量在0.65至0.85之间。在第一次选择试验中，腹腔注射硫酸铊产生的味觉厌恶很轻微，仅在最高剂量时出现。相比之下，在第一次选择试验中，口服硫酸铊除最低剂量外，在所有剂量下都导致明显的厌恶。第二次和第三次选择试验中的糖精偏好与第一次选择试验中的相似。这些结果表明，未能获得毒物诱导的味觉厌恶可能部分归因于毒物的给药途径。
