倍半萜类化合物及其细胞毒性活性。

Sesquiterpenes from and Their Cytotoxic Activity.

机构信息

Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Yeongdo-gu, Busan 49111, Republic of Korea.

Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanjiro, Cheongju 28116, Republic of Korea.

出版信息

Mar Drugs. 2023 Jun 16;21(6):361. doi: 10.3390/md21060361.

DOI:10.3390/md21060361

PMID:37367686

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10305546/

Abstract

Nine sesquiterpenes, including eight pentalenenes (-) and one bolinane derivative (), were isolated from the culture broth of a marine-derived actinobacterium 213DD-006. Among them, , , , and were new compounds. Their planar structures were determined by spectroscopic methods (HRMS, 1D, and 2D NMR), and the absolute configuration was established by biosynthesis consideration and electronic-circular-dichroism (ECD) calculations. All the isolated compounds were screened for their cytotoxicity against six solid and seven blood cancer cell lines. Compounds - and showed a moderate activity against all of the tested solid cell lines, with GI values ranging from 1.97 to 3.46 µM.

摘要

从海洋来源放线菌 213DD-006 的发酵液中分离得到 9 个倍半萜，包括 8 个五倍半萜烯（(-)）和 1 个博莱宁衍生物（）。其中，，，，和为新化合物。通过光谱方法（高分辨质谱、1D 和 2D NMR）确定了它们的平面结构，通过生物合成考虑和电子圆二色性（ECD）计算确定了它们的绝对构型。所有分离得到的化合物均对 6 种固体肿瘤细胞系和 7 种血液癌细胞系进行了细胞毒性筛选。化合物 - 和对所有测试的固体细胞系均表现出中等活性，GI 值范围为 1.97-3.46 µM。