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细胞膜的结构概念与超分子动力学的演变

Evolution of the Concepts of Architecture and Supramolecular Dynamics of the Plasma Membrane.

作者信息

Campos Muñiz Carolina, Fernández Perrino Francisco José

机构信息

Department of Health Sciences, Universidad Autónoma Metropolitana Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Mexico City 09340, Mexico.

Department of Biotechnology, Universidad Autónoma Metropolitana-Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, Mexico City 09340, Mexico.

出版信息

Membranes (Basel). 2023 May 24;13(6):547. doi: 10.3390/membranes13060547.

DOI:10.3390/membranes13060547
PMID:37367751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10305044/
Abstract

The plasma membrane (PM) has undergone important conceptual changes during the history of scientific research, although it is undoubtedly a cellular organelle that constitutes the first defining characteristic of cellular life. Throughout history, the contributions of countless scientists have been published, each one of them with an enriching contribution to the knowledge of the structure-location and function of each structural component of this organelle, as well as the interaction between these and other structures. The first published contributions on the plasmatic membrane were the transport through it followed by the description of the structure: lipid bilayer, associated proteins, carbohydrates bound to both macromolecules, association with the cytoskeleton and dynamics of these components.. The data obtained experimentally from each researcher were represented in graphic configurations, as a language that facilitates the understanding of cellular structures and processes. This paper presents a review of some of the concepts and models proposed about the plasma membrane, emphasizing the components, the structure, the interaction between them and the dynamics. The work is illustrated with resignified 3D diagrams to visualize the changes that occurred during the history of the study of this organelle. Schemes were redrawn in 3D from the original articles...

摘要

在科学研究的历史中，质膜（PM）经历了重要的概念性变化，尽管它无疑是一种细胞器，构成了细胞生命的首要决定性特征。纵观历史，无数科学家的贡献得以发表，他们每个人都为了解该细胞器每个结构成分的结构定位和功能，以及这些成分与其他结构之间的相互作用做出了丰富贡献。关于质膜的首批发表贡献是其物质运输，随后是对其结构的描述：脂质双层、相关蛋白质、与这两种大分子结合的碳水化合物、与细胞骨架的关联以及这些成分的动态变化。从每位研究人员通过实验获得的数据都以图形形式呈现，作为一种便于理解细胞结构和过程的语言。本文对一些关于质膜的概念和模型进行了综述，重点介绍了其成分、结构、它们之间的相互作用以及动态变化。这项工作通过重新设计的三维图进行说明，以可视化在该细胞器研究历史中发生的变化。示意图是从原始文章中重新绘制为三维形式的……

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/7b3705c9a142/membranes-13-00547-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/dcc2f0202e99/membranes-13-00547-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/8180b2cd0501/membranes-13-00547-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/fc8242811939/membranes-13-00547-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/f00bce25f5f6/membranes-13-00547-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/ac0ade1571d3/membranes-13-00547-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/6392a91e2f79/membranes-13-00547-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/98f472fc7e51/membranes-13-00547-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/7b3705c9a142/membranes-13-00547-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/dcc2f0202e99/membranes-13-00547-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/8180b2cd0501/membranes-13-00547-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/fc8242811939/membranes-13-00547-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/f00bce25f5f6/membranes-13-00547-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/ac0ade1571d3/membranes-13-00547-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/6392a91e2f79/membranes-13-00547-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/98f472fc7e51/membranes-13-00547-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a35a/10305044/7b3705c9a142/membranes-13-00547-g008.jpg

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本文引用的文献

1
Fifty Years of the Fluid-Mosaic Model of Biomembrane Structure and Organization and Its Importance in Biomedicine with Particular Emphasis on Membrane Lipid Replacement.生物膜结构与组织的流动镶嵌模型五十年及其在生物医学中的重要性，特别强调膜脂替代
Biomedicines. 2022 Jul 15;10(7):1711. doi: 10.3390/biomedicines10071711.
2
A Brief Introduction to Some Aspects of the Fluid-Mosaic Model of Cell Membrane Structure and Its Importance in Membrane Lipid Replacement.细胞膜结构的流体镶嵌模型若干方面简介及其在膜脂替代中的重要性
Membranes (Basel). 2021 Nov 29;11(12):947. doi: 10.3390/membranes11120947.
3
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape.
质膜在脂类不饱和程度、脂类双层的堆积和膜蛋白形状上都是不对称的。
Nat Chem Biol. 2020 Jun;16(6):644-652. doi: 10.1038/s41589-020-0529-6. Epub 2020 May 4.
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An agent-based model of molecular aggregation at the cell membrane.基于主体的细胞膜分子聚集模型。
PLoS One. 2020 Feb 7;15(2):e0226825. doi: 10.1371/journal.pone.0226825. eCollection 2020.
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Computational Modeling of Realistic Cell Membranes.真实细胞膜的计算建模。
Chem Rev. 2019 May 8;119(9):6184-6226. doi: 10.1021/acs.chemrev.8b00460. Epub 2019 Jan 9.
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Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine).P4-ATPases 的底物：超越氨基磷脂（磷脂酰丝氨酸和磷脂酰乙醇胺）。
FASEB J. 2019 Mar;33(3):3087-3096. doi: 10.1096/fj.201801873R. Epub 2018 Dec 3.
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Aquaporins: More Than Functional Monomers in a Tetrameric Arrangement.水通道蛋白：不仅仅是呈四聚体排列的功能性单体
Cells. 2018 Nov 11;7(11):209. doi: 10.3390/cells7110209.
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J Gen Physiol. 2018 Nov 5;150(11):1472-1483. doi: 10.1085/jgp.201812153. Epub 2018 Sep 25.
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Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374. doi: 10.1038/nrm.2017.16. Epub 2017 Mar 30.
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There Is No Simple Model of the Plasma Membrane Organization.不存在简单的质膜组织模型。
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