甜菜碱和可溶性纤维可改善慢性肾脏病猫的身体成分和血浆代谢物。

Betaine and Soluble Fiber Improve Body Composition and Plasma Metabolites in Cats with Chronic Kidney Disease.

机构信息

Pet Nutrition Center, Hill's Pet Nutrition, Inc., Topeka, KS 66617, USA.

Department of Grain Science and Industry, Kansas State University, Manhattan, KS 66506, USA.

出版信息

Front Biosci (Elite Ed). 2023 Apr 4;15(2):8. doi: 10.31083/j.fbe1502008.

DOI:10.31083/j.fbe1502008

PMID:37369569

Abstract

BACKGROUND

Chronic kidney disease (CKD) is a common condition in cats and cachexia (loss of lean body mass) is a concern. A nutrition-based intervention was investigated in cats with CKD for its effects on body composition, the plasma metabolome, and possible implications on health.

METHODS

After a 4-week prefeed period with the control food, cats with CKD (N = 24) were randomized to one of six groups to consume a control food; a food supplemented with 0.5% betaine, 0.39% oat beta-glucan, and 0.27% short-chain fructooligosaccharides (scFOS, test food 1); and a food supplemented with 0.5% betaine, 0.59% oat beta-glucan, and 0.41% scFOS (test food 2) in a William's Latin Square design, each for 10 weeks. Body composition was assessed via dual-energy X-ray absorptiometry measurements, and the plasma metabolome was characterized.

RESULTS

Despite no significant differences in daily intake among the three foods, significant increases in total body mass, lean body mass, and lean plus bone mineral composition were observed when cats with CKD consumed test food 1 compared with the control food; numerical increases were seen with test food 2 versus the control food. Plasma metabolomics indicated increased one-carbon metabolism following consumption of test food 1 and/or 2, with significant increases in sarcosine and numerical increases in methionine. Lower levels of plasma trans-4-hydroxyproline and N-methylproline following consumption of test foods 1 and 2 indicates reduced collagen breakdown and perhaps reduced fibrosis. Several acylcarnitines and branched-chain fatty acids associated with CKD were also reduced when cats ate test food 1 or 2 versus the control food. Higher plasma levels of sphingomyelins with consumption of test food 1 or 2 may reflect less severe CKD.

CONCLUSIONS

Consumption of foods with supplemental betaine and fibers by cats with CKD led to improvements in body composition and changes in the plasma metabolome that correspond to better kidney health.

摘要

背景

慢性肾脏病（CKD）是猫的常见病症，而消瘦（去脂体重减少）是一个令人关注的问题。本研究调查了一种基于营养的干预措施对 CKD 猫的身体成分、血浆代谢组学的影响，以及其对健康的可能影响。

方法

在使用对照食物进行 4 周预饲期后，24 只 CKD 猫被随机分为 6 组，分别食用对照食物、添加 0.5%甜菜碱、0.39%燕麦β-葡聚糖和 0.27%短链果聚糖（scFOS，试验食物 1）、添加 0.5%甜菜碱、0.59%燕麦β-葡聚糖和 0.41%scFOS（试验食物 2）的食物，采用威廉斯拉丁方设计，每种食物喂养 10 周。通过双能 X 射线吸收法测量身体成分，并对血浆代谢组进行了特征分析。

结果

尽管三种食物的日摄入量无显著差异，但与对照食物相比，CKD 猫食用试验食物 1 时，总体重、去脂体重和瘦加骨矿物质成分均显著增加；与对照食物相比，试验食物 2 也出现了数值增加。血浆代谢组学表明，食用试验食物 1 和/或 2 后，一碳代谢增加，肌氨酸显著增加，蛋氨酸数值增加。与食用对照食物相比，食用试验食物 1 和 2 后，血浆中反式-4-羟脯氨酸和 N-甲基脯氨酸的水平降低，表明胶原分解减少，纤维化程度可能降低。当猫食用试验食物 1 或 2 时，几种与 CKD 相关的酰基肉碱和支链脂肪酸也减少。与食用对照食物相比，食用试验食物 1 或 2 时，神经鞘磷脂的血浆水平升高，可能表明 CKD 病情较轻。