The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807-8555, Fukuoka, Japan.
Biomolecules. 2023 Jun 8;13(6):960. doi: 10.3390/biom13060960.
The treatment of rheumatoid arthritis was revolutionized with the use of molecular-targeted drugs that target immunoregulatory molecules. The success of treatment with these drugs prompted the development of molecular-targeted drugs for systemic lupus erythematosus. However, systemic lupus erythematosus is a disease with high heterogeneous immune abnormalities, and diverse cells or molecules can be treatment targets. Thus, the identification of subpopulations based on immune abnormalities is essential for the development of effective treatment. One analytical method used to identify subpopulations is the immunophenotyping of peripheral blood samples of patients. This analysis evaluates the validity of target molecules for peripheral blood immune cell subsets, which are expected to be developed as biomarkers for precision medicine in which appropriate treatment targets are set for each subpopulation.
类风湿关节炎的治疗随着免疫调节分子的靶向药物的应用而发生了革命性的变化。这些药物治疗的成功促使人们开发了针对系统性红斑狼疮的靶向药物。然而，系统性红斑狼疮是一种免疫异常高度异质性的疾病，多种细胞或分子都可以作为治疗靶点。因此，基于免疫异常来鉴定亚群对于开发有效的治疗方法至关重要。一种用于鉴定亚群的分析方法是对患者外周血样本进行免疫表型分析。这种分析评估了目标分子在外周血免疫细胞亚群中的有效性，这些亚群有望成为精准医学的生物标志物，为每个亚群设定合适的治疗靶点。
