Patnaik Soumya, Nathan Sriram, Kar Biswajit, Gregoric Igor D, Li Yi-Ping
Division of Cardiology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Department of Advanced Cardiopulmonary Therapies and Transplantation, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Biomedicines. 2023 May 27;11(6):1557. doi: 10.3390/biomedicines11061557.
In the early 1960s, heat shock proteins (HSPs) were first identified as vital intracellular proteinaceous components that help in stress physiology and reprogram the cellular responses to enable the organism's survival. By the early 1990s, HSPs were detected in extracellular spaces and found to activate gamma-delta T-lymphocytes. Subsequent investigations identified their association with varied disease conditions, including autoimmune disorders, diabetes, cancer, hepatic, pancreatic, and renal disorders, and cachexia. In cardiology, extracellular HSPs play a definite, but still unclear, role in atherosclerosis, acute coronary syndromes, and heart failure. The possibility of HSP-targeted novel molecular therapeutics has generated much interest and hope in recent years. In this review, we discuss the role of Extracellular Heat Shock Proteins (Ec-HSPs) in various disease states, with a particular focus on cardiovascular diseases.
20世纪60年代初，热休克蛋白（HSPs）首次被确认为重要的细胞内蛋白质成分，有助于应激生理学，并重新编程细胞反应以使生物体存活。到20世纪90年代初，在细胞外空间检测到热休克蛋白，并发现其可激活γ-δ T淋巴细胞。随后的研究确定了它们与多种疾病状态的关联，包括自身免疫性疾病、糖尿病、癌症、肝脏、胰腺和肾脏疾病以及恶病质。在心脏病学中，细胞外热休克蛋白在动脉粥样硬化、急性冠状动脉综合征和心力衰竭中发挥着明确但仍不清楚的作用。近年来，以热休克蛋白为靶点的新型分子疗法的可能性引起了人们极大的兴趣和希望。在这篇综述中，我们讨论细胞外热休克蛋白（Ec-HSPs）在各种疾病状态中的作用，特别关注心血管疾病。
