Leumann E P
Padiatr Padol. 1986;21(2):155-62.
Adequate nutrition plays a key role in the conservative management of chronic renal failure. Recent experience favours initiation of dietary measures at an earlier stage of renal failure (RF) than hitherto advocated. The requirements of protein and energy are preferably calculated according to height rather than age. Protein intake is often far in excess of the recommended (minimum) intake of 0.25 g per cm body height (taken as 100%). With the aim to keep serum urea concentration close to normal, intake in mild RF (GFR 33-50 ml/min per 1.73 m2) is restricted to 150%, in moderate RF (15-33 ml/min) to 120%, and in severe RF (less than 15 ml/min) to the minimum. High quality protein (greater than 70% of animal origin) is advocated in case of severe restriction. Further limitations are possible with administration of essential amino acids and keto analogues. Energy requirements vary with height (56-75 kJ per cm body height). Many patients require a supplementation, e.g. oligosaccharides. Intestinal phosphate absorption (and renal excretion) is adjusted according to the degree of RF by reduction of intake and administration of phosphate binders (aluminium hydroxide or calcium carbonate). Vitamin D is now often given as one of its polar metabolites. Severe dietary restrictions require a high motivation of the patient, family and staff and are only successful when a good state of health can be maintained.
充足的营养在慢性肾衰竭的保守治疗中起着关键作用。近期经验表明,应在肾衰竭(RF)的早期阶段而非如以往所提倡的那样,更早地启动饮食措施。蛋白质和能量的需求量最好根据身高而非年龄来计算。蛋白质摄入量往往远远超过推荐的(最低)摄入量,即每厘米身高0.25克(计为100%)。为使血清尿素浓度接近正常,轻度肾衰竭(肾小球滤过率[GFR]为每1.73平方米33 - 50毫升/分钟)时摄入量限制为150%,中度肾衰竭(15 - 33毫升/分钟)时为120%,重度肾衰竭(低于15毫升/分钟)时为最低摄入量。在严格限制的情况下,提倡摄入优质蛋白质(动物源性蛋白质占比大于70%)。使用必需氨基酸和酮类似物可能会有进一步的限制。能量需求因身高而异(每厘米身高56 - 75千焦)。许多患者需要补充营养,例如低聚糖。根据肾衰竭的程度,通过减少摄入量和使用磷结合剂(氢氧化铝或碳酸钙)来调节肠道磷吸收(及肾脏排泄)。现在维生素D常以其极性代谢产物之一的形式给药。严格的饮食限制需要患者、家属和医护人员有高度的积极性,并且只有在能够维持良好健康状态时才会成功。